Higher-order epistasis and phenotypic prediction
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2020.10.14.339804
Abstract: Contemporary high-throughput mutagenesis experiments are providing an increasingly detailed view of the complex patterns of genetic interaction that occur between multiple mutations within a single protein or regulatory element. By simultaneously measuring the effects of… read more here.
Keywords: order epistasis; higher order; genetic interaction; phenotypic ... See more keywords
PyToxo: a Python tool for calculating penetrance tables of high-order epistasis models
Sign Up to like & getrecommendations! Published in 2022 at "BMC Bioinformatics"
DOI: 10.1186/s12859-022-04645-7
Abstract: Background Epistasis is the interaction between different genes when expressing a certain phenotype. If epistasis involves more than two loci it is called high-order epistasis. High-order epistasis is an area under active research because it… read more here.
Keywords: order; penetrance; epistasis; order epistasis ... See more keywords