Abstract 862: Pairwise and higher-order epistatic effects among somatic cancer mutations across oncogenesis of lung adenocarcinoma
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DOI: 10.1158/1538-7445.am2023-862
Abstract: The somatic evolution of cancer depends on the rate at which new mutations are acquired, as well as the selective pressure acting on them. Further, mutual exclusivity or co-occurrence of mutations suggests that variants can… read more here.
Keywords: pairwise higher; higher order; lung; order epistatic ... See more keywords
An Ultrahigh-Dimensional Mapping Model of High-order Epistatic Networks for Complex Traits
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DOI: 10.2174/1389202919666171218162210
Abstract: Background: Genetic interactions involving more than two loci have been thought to affect quantitatively inherited traits and diseases more pervasively than previously appreciated. However, the detection of such high-order interactions to chart a complete portrait… read more here.
Keywords: mapping; order epistatic; model; high order ... See more keywords
MDSN: A Module Detection Method for Identifying High-Order Epistatic Interactions
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DOI: 10.3390/genes13122403
Abstract: Epistatic interactions are referred to as SNPs (single nucleotide polymorphisms) that affect disease development and trait expression nonlinearly, and hence identifying epistatic interactions plays a great role in explaining the pathogenesis and genetic heterogeneity of… read more here.
Keywords: epistatic interactions; high order; module detection; order ... See more keywords