Higher‐order structure formation using refined monomer structures of lipid raft markers, Stomatin, Prohibitin, Flotillin, and HflK/C‐related proteins
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13593
Abstract: Currently, information on the higher‐order structure of Stomatin, Prohibitin, Flotillin, and HflK/C (SPFH)‐domain proteins is limited. Briefly, the coordinate information (Refined PH1511.pdb) of the stomatin ortholog, PH1511 monomer, was obtained using the artificial intelligence, ColabFold:… read more here.
Keywords: structure; higher order; hflk; stomatin prohibitin ... See more keywords
Assessment of the higher order structure of Humira®, Remicade®, Avastin®, Rituxan®, Herceptin®, and Enbrel® by 2D‐NMR fingerprinting
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.09.056
Abstract: &NA; The advent of monoclonal antibody biosimilar products has stimulated the development of analytical methods that can better characterize an important quality attribute, namely the higher order structure (HOS). Here, we propose a simple approach… read more here.
Keywords: rituxan; assessment higher; order structure; higher order ... See more keywords
NMR based quality evaluation of mAb therapeutics: A proof of concept higher order structure biosimilarity assessment of trastuzumab biosimilars.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2022.114710
Abstract: Higher-order structural (HOS) biosimilarity assessment is a regulatory requirement for intended biosimilars, and manufacturers are required to demonstrate the biosimilarity of their product in comparison to the reference product concerning both safety and efficacy. NMR… read more here.
Keywords: biosimilarity assessment; biosimilarity; order structure; assessment ... See more keywords
Effect of Polysorbate 20 and Polysorbate 80 on the Higher-Order Structure of a Monoclonal Antibody and Its Fab and Fc Fragments Probed Using 2D Nuclear Magnetic Resonance Spectroscopy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.08.011
Abstract: We examined how polysorbate 20 (PS20; Tween 20) and polysorbate 80 (PS80; Tween 80) affect the higher-order structure of a monoclonal antibody (mAb) and its antigen-binding (Fab) and crystallizable (Fc) fragments, using near-UV circular dichroism… read more here.
Keywords: polysorbate; structure monoclonal; higher order; spectroscopy ... See more keywords
Higher-order Structure of Human Chromosomes Observed by Electron Tomography and Electron Diffraction
Sign Up to like & getrecommendations! Published in 2020 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927620015421
Abstract: Chromosome higher-order structure has been an enigma for over a century. Proposed models include radial loop model, radial coil model, folded fiber model and helical coiling of radial loops model [1]. These models are based… read more here.
Keywords: chromosomes observed; order structure; electron; structure ... See more keywords
Comparative Analysis of One-Dimensional Protein Fingerprint by Line Shape Enhancement and Two-Dimensional 1H,13C Methyl NMR Methods for Characterization of the Higher Order Structure of IgG1 Monoclonal Antibodies
Sign Up to like & getrecommendations! Published in 2020 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.9b05385
Abstract: The use of NMR spectroscopy has emerged as a premier tool to characterize the higher order structure of protein therapeutics and in particular IgG1 monoclonal antibodies (mAbs). Due to their large ... read more here.
Keywords: igg1 monoclonal; higher order; order structure; monoclonal antibodies ... See more keywords
A Biopharmaceutical Perspective on Higher-Order Structure and Thermal Stability of mRNA Vaccines
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DOI: 10.1021/acs.molpharmaceut.2c00092
Abstract: Preservation of the integrity of macromolecular higher-order structure is a tenet central to achieving biologic drug and vaccine product stability toward manufacturing, distribution, storage, handling, and administration. Given that mRNA lipid nanoparticles (mRNA-LNPs) are held… read more here.
Keywords: structure; mrna vaccines; mrna; higher order ... See more keywords
Higher-order structure of polymer melt described by persistent homology
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-80975-5
Abstract: The optimal method of the polymer Materials Informatics (MI) has not been developed because the amorphous nature of the higher-order structure affects these properties. We have now tried to develop the polymer MI’s descriptor of… read more here.
Keywords: order; polymer; higher order; persistent homology ... See more keywords
Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb
Sign Up to like & getrecommendations! Published in 2023 at "mAbs"
DOI: 10.1080/19420862.2022.2160227
Abstract: ABSTRACT The clinical efficacy and safety of protein-based drugs such as monoclonal antibodies (mAbs) rely on the integrity of the protein higher order structure (HOS) during product development, manufacturing, storage, and patient administration. As mAb-based… read more here.
Keywords: order structure; correlated analytical; higher order; analytical functional ... See more keywords
Fiber-Like Organization as a Basic Principle for Euchromatin Higher-Order Structure
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.784440
Abstract: A detailed understanding of the principles of the structural organization of genetic material is of great importance for elucidating the mechanisms of differential regulation of genes in development. Modern ideas about the spatial organization of… read more here.
Keywords: higher order; order structure; fiber like; chromatin ... See more keywords