Orexin‐A increases the firing activity of hippocampal CA1 neurons through orexin‐1 receptors
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23975
Abstract: Orexins including two peptides, orexin‐A and orexin‐B, are produced in the posterior lateral hypothalamus. Much evidence has indicated that central orexinergic systems play numerous functions including energy metabolism, feeding behavior, sleep/wakefulness, and neuroendocrine and sympathetic… read more here.
Keywords: orexin; ca1 neurons; ca1; firing activity ... See more keywords
Orexin supplementation in narcolepsy treatment: A review
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DOI: 10.1002/med.21550
Abstract: Narcolepsy is a rare, chronic neurological disease characterized by excessive daytime sleepiness, cataplexy, vivid hallucinations, and sleep paralysis. Narcolepsy occurs in approximately 1 of 3000 people, affecting mainly adolescents aged 15 to 30 years. Recently,… read more here.
Keywords: orexin; narcolepsy treatment; orexin supplementation; supplementation narcolepsy ... See more keywords
Proteomic profiling of the hypothalamus in two mouse models of narcolepsy
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DOI: 10.1002/pmic.201600478
Abstract: Narcolepsy is a disabling neurological disorder of sleepiness linked to the loss of neurons producing orexin neuropeptides in the hypothalamus. Two well‐characterized phenotypic mouse models of narcolepsy, loss‐of‐function (orexin‐knockout), and progressive loss of orexin (orexin/ataxin‐3)… read more here.
Keywords: models narcolepsy; orexin; mouse models; hypothalamus two ... See more keywords
Effects of selective orexin receptor‐2 and cannabinoid receptor‐1 antagonists on the response of medial prefrontal cortex neurons to tramadol
Sign Up to like & getrecommendations! Published in 2022 at "Synapse"
DOI: 10.1002/syn.22232
Abstract: Tramadol is widely used to control pain in various diseases, but the relevant mechanisms are less known despite the severe risks of abuse. The medial prefrontal cortex (mPFC) is one of the critical centers of… read more here.
Keywords: orexin; orexin receptor; medial prefrontal; receptor ... See more keywords
Orexin/Hypocretin Signaling.
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DOI: 10.1007/7854_2016_49
Abstract: Orexin/hypocretin peptide (orexin-A and orexin-B) signaling is believed to take place via the two G-protein-coupled receptors (GPCRs), named OX1 and OX2 orexin receptors, as described in the previous chapters. Signaling of orexin peptides has been… read more here.
Keywords: signaling orexin; orexin; hypocretin signaling; orexin hypocretin ... See more keywords
Role of the Orexin/Hypocretin System in Stress-Related Psychiatric Disorders.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2016_56
Abstract: Orexins (hypocretins) are critically involved in coordinating appropriate physiological and behavioral responses to aversive and threatening stimuli. Acute stressors engage orexin neurons via direct projections from stress-sensitive brain regions. Orexin neurons, in turn, facilitate adaptive… read more here.
Keywords: orexin; system; stress; role orexin ... See more keywords
Spinal Orexin-2 Receptors are Involved in Modulation of the Lateral Hypothalamic Stimulation-Induced Analgesia
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DOI: 10.1007/s11064-019-02749-w
Abstract: Role of the orexinergic system in pain modulation is well studied and involvement of the spinal orexin-1 receptors is well documented. In this study, we examined role of the spinal orexin-2 receptors in modulation of… read more here.
Keywords: orexin receptors; orexin; spinal orexin; stimulation ... See more keywords
Localization of orexin B and orexin-2 receptor in the rat epididymis.
Sign Up to like & getrecommendations! Published in 2018 at "Acta histochemica"
DOI: 10.1016/j.acthis.2018.02.011
Abstract: The peptides orexin A (OXA) and orexin B (OXB) derived from the proteolytic cleavage of a common precursor molecule, prepro-orexin, were originally described in the rat hypothalamus. Successively, they have been found in many other… read more here.
Keywords: orexin; rat epididymis; ox2r; receptor ... See more keywords
Orexin signaling during social defeat stress influences subsequent social interaction behaviour and recognition memory
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DOI: 10.1016/j.bbr.2018.05.032
Abstract: &NA; Orexins are neuropeptides synthesized in the lateral hypothalamus that influence arousal, feeding, reward pathways, and the response to stress. However, the role of orexins in repeated stress is not fully characterized. Here, we examined… read more here.
Keywords: orexin; social defeat; recognition; stress ... See more keywords
Non-selective orexin-receptor antagonist attenuates stress-re-stress-induced core PTSD-like symptoms in rats: Behavioural and neurochemical analyses
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DOI: 10.1016/j.bbr.2020.113015
Abstract: Post-traumatic stress disorder (PTSD) is a psychological disorder affecting many around the world. Growing evidence suggests that orexin-A is involved in the pathophysiology of depression and panic anxiety disorder. However, the role of orexin-A in… read more here.
Keywords: orexin; stress stress; stress; like symptoms ... See more keywords
Orexin activated emergence from isoflurane anaesthesia involves excitation of ventral tegmental area dopaminergic neurones in rats.
Sign Up to like & getrecommendations! Published in 2019 at "British journal of anaesthesia"
DOI: 10.1016/j.bja.2019.07.005
Abstract: BACKGROUND Orexin can facilitate emergence after general anaesthesia via multiple neural pathways. Dopaminergic neurones in the ventral tegmental area (VTA) participate in behavioural arousal from anaesthesia. We investigated the regulation of dopaminergic VTA neurones by… read more here.
Keywords: orexin; isoflurane anaesthesia; anaesthesia; dopaminergic neurones ... See more keywords