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   Articles with "orexin" as a keyword



orexin B alleviates sepsis‐associated lung injury through the attenuation of pulmonary endothelial barrier dysfunction by regulating the rho‐associated coiled‐coil containing protein kinase 2/zonula occludens‐1 (ROCK2/ZO‐1) axis

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recommendations! Published in 2024 at "Biotechnology and Applied Biochemistry"

DOI: 10.1002/bab.2703

Abstract: Dysfunction of the alveolar endothelial barrier plays a crucial role in the pathogenesis of septic acute lung injury (ALI). orexin B is a neuropeptide derived from orexin neurons in the lateral hypothalamus and has multiple… read more here.

Keywords: mice; lung; lung injury; orexin ... See more keywords

Orexin‐A increases the firing activity of hippocampal CA1 neurons through orexin‐1 receptors

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recommendations! Published in 2017 at "Journal of Neuroscience Research"

DOI: 10.1002/jnr.23975

Abstract: Orexins including two peptides, orexin‐A and orexin‐B, are produced in the posterior lateral hypothalamus. Much evidence has indicated that central orexinergic systems play numerous functions including energy metabolism, feeding behavior, sleep/wakefulness, and neuroendocrine and sympathetic… read more here.

Keywords: orexin; ca1 neurons; ca1; firing activity ... See more keywords

The role of orexin in Parkinson's disease

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recommendations! Published in 2024 at "Journal of Neuroscience Research"

DOI: 10.1002/jnr.25322

Abstract: Emerging evidence has implicated the orexin system in non‐motor pathogenesis of Parkinson's disease. It has also been suggested the orexin system is involved in the modulation of motor control, further implicating the orexin system in… read more here.

Keywords: system; disease; orexin; motor ... See more keywords

Orexin supplementation in narcolepsy treatment: A review

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recommendations! Published in 2019 at "Medicinal Research Reviews"

DOI: 10.1002/med.21550

Abstract: Narcolepsy is a rare, chronic neurological disease characterized by excessive daytime sleepiness, cataplexy, vivid hallucinations, and sleep paralysis. Narcolepsy occurs in approximately 1 of 3000 people, affecting mainly adolescents aged 15 to 30 years. Recently,… read more here.

Keywords: orexin; narcolepsy treatment; orexin supplementation; supplementation narcolepsy ... See more keywords

Proteomic profiling of the hypothalamus in two mouse models of narcolepsy

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recommendations! Published in 2017 at "PROTEOMICS"

DOI: 10.1002/pmic.201600478

Abstract: Narcolepsy is a disabling neurological disorder of sleepiness linked to the loss of neurons producing orexin neuropeptides in the hypothalamus. Two well‐characterized phenotypic mouse models of narcolepsy, loss‐of‐function (orexin‐knockout), and progressive loss of orexin (orexin/ataxin‐3)… read more here.

Keywords: models narcolepsy; orexin; mouse models; hypothalamus two ... See more keywords

Effects of selective orexin receptor‐2 and cannabinoid receptor‐1 antagonists on the response of medial prefrontal cortex neurons to tramadol

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recommendations! Published in 2022 at "Synapse"

DOI: 10.1002/syn.22232

Abstract: Tramadol is widely used to control pain in various diseases, but the relevant mechanisms are less known despite the severe risks of abuse. The medial prefrontal cortex (mPFC) is one of the critical centers of… read more here.

Keywords: orexin; orexin receptor; medial prefrontal; receptor ... See more keywords

Orexin/Hypocretin Signaling.

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recommendations! Published in 2017 at "Current topics in behavioral neurosciences"

DOI: 10.1007/7854_2016_49

Abstract: Orexin/hypocretin peptide (orexin-A and orexin-B) signaling is believed to take place via the two G-protein-coupled receptors (GPCRs), named OX1 and OX2 orexin receptors, as described in the previous chapters. Signaling of orexin peptides has been… read more here.

Keywords: signaling orexin; orexin; hypocretin signaling; orexin hypocretin ... See more keywords

Role of the Orexin/Hypocretin System in Stress-Related Psychiatric Disorders.

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recommendations! Published in 2017 at "Current topics in behavioral neurosciences"

DOI: 10.1007/7854_2016_56

Abstract: Orexins (hypocretins) are critically involved in coordinating appropriate physiological and behavioral responses to aversive and threatening stimuli. Acute stressors engage orexin neurons via direct projections from stress-sensitive brain regions. Orexin neurons, in turn, facilitate adaptive… read more here.

Keywords: orexin; system; stress; role orexin ... See more keywords

A new direction for adjunctive therapy of difficult-to-treat depression: examining the role of orexin receptor antagonists

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recommendations! Published in 2025 at "European Archives of Psychiatry and Clinical Neuroscience"

DOI: 10.1007/s00406-025-01999-w

Abstract: One of the several pressing unmet needs in the pharmacotherapy of MDD is development of drugs with novel mechanisms of action that can effectively treat depressed patients who do not respond to first- and second-line… read more here.

Keywords: difficult treat; orexin; orexin receptor; receptor antagonists ... See more keywords

Roles of orexinergic and noradrenergic neuronal activity in ketamine-induced sedation: a study using an orexin-ataxin-3 transgenic rat model

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recommendations! Published in 2025 at "Journal of Anesthesia"

DOI: 10.1007/s00540-025-03521-x

Abstract: To investigate the role of brain noradrenergic and orexinergic activity in ketamine-induced sedation. We used orexin neuron-deficient transgenic rats (orexin/ataxin-3) and wild-type controls. Noradrenaline and orexin levels were measured in the pons, hypothalamus, and cerebral… read more here.

Keywords: ketamine induced; orexin; wild type; activity ... See more keywords

Spinal Orexin-2 Receptors are Involved in Modulation of the Lateral Hypothalamic Stimulation-Induced Analgesia

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recommendations! Published in 2019 at "Neurochemical Research"

DOI: 10.1007/s11064-019-02749-w

Abstract: Role of the orexinergic system in pain modulation is well studied and involvement of the spinal orexin-1 receptors is well documented. In this study, we examined role of the spinal orexin-2 receptors in modulation of… read more here.

Keywords: orexin receptors; orexin; spinal orexin; stimulation ... See more keywords