Orexin/Hypocretin Signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2016_49
Abstract: Orexin/hypocretin peptide (orexin-A and orexin-B) signaling is believed to take place via the two G-protein-coupled receptors (GPCRs), named OX1 and OX2 orexin receptors, as described in the previous chapters. Signaling of orexin peptides has been… read more here.
Keywords: signaling orexin; orexin; hypocretin signaling; orexin hypocretin ... See more keywords
Orexin (hypocretin) and addiction
Sign Up to like & getrecommendations! Published in 2021 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2021.09.002
Abstract: Although originally implicated in appetite and sleep/wakefulness, the hypothalamic orexin (hypocretin) system has now been demonstrably linked with motivated behavior. This highly plastic system responds to reward-associated environmental stimuli and becomes pathologically overactive in addicted… read more here.
Keywords: orexin; hypocretin addiction; system; orexin hypocretin ... See more keywords
Orexin/hypocretin system dysfunction in patients with Takotsubo syndrome: A novel pathophysiological explanation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1016369
Abstract: Takotsubo syndrome (TTS) is an acute heart failure syndrome. Emotional or physical stressors are believed to precipitate TTS, while the pathophysiological mechanism is not yet completely understood. During the coronavirus disease (COVID-19) pandemic, an increased… read more here.
Keywords: orexin hypocretin; system; system dysfunction; orexin ... See more keywords
The Anti-tumoral Properties of Orexin/Hypocretin Hypothalamic Neuropeptides: An Unexpected Therapeutic Role
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DOI: 10.3389/fendo.2018.00573
Abstract: Orexins (OxA and OxB) also termed hypocretins are hypothalamic neuropeptides involved in central nervous system (CNS) to control the sleep/wake process which is mediated by two G protein-coupled receptor subtypes, OX1R, and OX2R. Beside these… read more here.
Keywords: tumoral properties; hypothalamic neuropeptides; anti tumoral; role ... See more keywords
Effects of Intranasal Orexin-A (Hypocretin-1) Administration on Neuronal Activation, Neurochemistry, and Attention in Aged Rats
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DOI: 10.3389/fnagi.2019.00362
Abstract: Cognitive function represents a key determinative factor for independent functioning among the elderly, especially among those with age-related cognitive disorders. However; existing pharmacotherapeutic tactics for treating these disorders provide only modest benefits on cognition. The… read more here.
Keywords: administration; age related; related cognitive; orexin hypocretin ... See more keywords
Orexin/Hypocretin and MCH Neurons: Cognitive and Motor Roles Beyond Arousal
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.639313
Abstract: The lateral hypothalamus (LH) is classically implicated in sleep-wake control. It is the main source of orexin/hypocretin and melanin-concentrating hormone (MCH) neuropeptides in the brain, which have been both implicated in arousal state switching. These… read more here.
Keywords: cognitive motor; mch neurons; orexin hypocretin; orexin mch ... See more keywords