Obstructive sleep apnea may induce orexinergic system and cerebral β-amyloid metabolism dysregulation: is it a further proof for Alzheimer's disease risk?
Sign Up to like & getrecommendations! Published in 2019 at "Sleep medicine"
DOI: 10.1016/j.sleep.2019.01.003
Abstract: BACKGROUND Obstructive Sleep Apnea (OSA) is associated with pathological changes of cerebral β-amyloid dynamics. Orexin has been demonstrated interfering with β-amyloid metabolism in Alzheimer's Disease (AD) pathology. The present study investigated cerebrospinal-fluid (CSF) β-amyloid40 (Aβ40),… read more here.
Keywords: cerebral amyloid; orexin levels; csf; osa patients ... See more keywords
Differences in serum orexin-A levels between the acute and subacute withdrawal phases in individuals who use methamphetamine.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and clinical psychopharmacology"
DOI: 10.1037/pha0000395
Abstract: Orexin has been suggested to play a role in regulating the reward circuits and enhancing drug-seeking behaviors; however, its role in methamphetamine (METH) addiction remains unclear. We previously found that blood orexin-A levels are upregulated… read more here.
Keywords: orexin; orexin levels; serum orexin; individuals use ... See more keywords
A higher body mass index in Chinese inpatients with chronic schizophrenia is associated with elevated plasma orexin-A levels and fewer negative symptoms
Sign Up to like & getrecommendations! Published in 2020 at "Nordic Journal of Psychiatry"
DOI: 10.1080/08039488.2020.1755995
Abstract: Abstract Objective: Orexin-A is involved in numerous physiological functions, such as feeding behavior and energy balance. Yet, the associations among the orexin system, weight changes and the clinical symptoms of schizophrenia patients remain uncertain, especially… read more here.
Keywords: orexin; schizophrenia; plasma orexin; orexin levels ... See more keywords
Orexin a levels of adolescents with major depressive disorder.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of psychiatry in clinical practice"
DOI: 10.1080/13651501.2021.1927106
Abstract: OBJECTIVE This study examines orexin A levels in adolescents with major depressive disorder (MDD). METHODS Serum orexin A levels of adolescents with MDD (n = 40) were compared to healthy controls (n = 38) using ANCOVA test. In addition,… read more here.
Keywords: orexin; depressive disorder; orexin levels; major depressive ... See more keywords
Plasma orexin‐A levels in patients with delirium
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DOI: 10.1111/psyg.12444
Abstract: The pathophysiology of delirium remains poorly understood. Recently, the sleep medication suvorexant, an orexin receptor antagonist, showed a preventive effect on delirium. However, it remains unclear whether regulation of orexin by suvorexant directly affects the… read more here.
Keywords: orexin; levels patients; plasma orexin; orexin levels ... See more keywords
Cerebrospinal fluid orexin-A levels in systemic lupus erythematosus patients presenting with excessive daytime sleepiness
Sign Up to like & getrecommendations! Published in 2018 at "Lupus"
DOI: 10.1177/0961203318778767
Abstract: Objective Involvement of the hypothalamus is rare in patients with systemic lupus erythematosus (SLE). In this study, we measured cerebrospinal fluid (CSF) orexin-A levels in SLE patients with hypothalamic lesions to investigate whether the orexin… read more here.
Keywords: orexin; orexin levels; systemic lupus; lupus erythematosus ... See more keywords
The relationship between orexin levels and blood pressure changes in patients with narcolepsy
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DOI: 10.1371/journal.pone.0185975
Abstract: Study objective Narcolepsy type 1 (NT1) is caused by a deficiency or absence of the neurotransmitter orexin. NT1 is also associated with a reduced nocturnal “dipping” of blood pressure (BP). The study objective was to… read more here.
Keywords: orexin levels; orexin; patients narcolepsy; blood pressure ... See more keywords
Orexin-A in Patients With Lewy Body Disease: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.765701
Abstract: Background Abnormal orexin-A levels in cerebrospinal fluid (CSF) have been identified in Alzheimer’s disease (AD) and other neurodegenerative diseases. However, few studies have focused on Lewy body disease (LBD) and often with debatable outcomes. Thus,… read more here.
Keywords: body disease; lewy body; systematic review; orexin levels ... See more keywords
Reduction of Orexin-A Is Associated With Anxiety and the Level of Depression of Male Methamphetamine Users During the Initial Withdrawal Period
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.900135
Abstract: Background Orexin has been linked to the regulation of reward and motivation in animals, but there have been few human studies to validate its regulatory effects. We aimed to determine how orexin-A levels changed during… read more here.
Keywords: orexin; abstinence; meth users; depression ... See more keywords