Role of the Orexin/Hypocretin System in Stress-Related Psychiatric Disorders.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2016_56
Abstract: Orexins (hypocretins) are critically involved in coordinating appropriate physiological and behavioral responses to aversive and threatening stimuli. Acute stressors engage orexin neurons via direct projections from stress-sensitive brain regions. Orexin neurons, in turn, facilitate adaptive… read more here.
Keywords: orexin; system; stress; role orexin ... See more keywords
Orexin as a modulator of fear-related behavior: Hypothalamic control of noradrenaline circuit
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2018.11.032
Abstract: Fear is an important physiological function for survival. It appears when animals or humans are confronted with an environmental threat. The amygdala has been shown to play a highly important role in emergence of fear.… read more here.
Keywords: orexin; related behavior; fear; orexin modulator ... See more keywords
Insulin-like growth factor I mitigates post-traumatic stress by inhibiting AMP-kinase in orexin neurons
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Psychiatry"
DOI: 10.1038/s41380-022-01442-9
Abstract: Maladaptive coping behaviors are probably involved in post-traumatic stress disorders (PTSD), but underlying mechanisms are incompletely understood. We now report that mice lacking functional insulin-like growth factor I (IGF-I) receptors in orexin neurons of the… read more here.
Keywords: insulin like; post traumatic; traumatic stress; orexin neurons ... See more keywords
The effect of orexin on the hypoxic ventilatory response of female rats is greatest in the active phase during diestrus.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00661.2022
Abstract: We recently showed that in male rats, orexin contributes to the hypoxic ventilatory response (HVR), with a stronger effect in the active phase. The effect of orexin on the HVR in females has not been… read more here.
Keywords: active phase; effect; orexin neurons; diestrus ... See more keywords
Interaction between Orexin Neurons and Monoaminergic Systems.
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers of neurology and neuroscience"
DOI: 10.1159/000514955
Abstract: Orexins have received a lot of attention as potent endogenous arousal-promoting peptides, and orexin receptor antagonists have shown clinical efficacy for the treatment of insomnia. Orexin neurons are thought to act primarily on monoaminergic neurons… read more here.
Keywords: monoaminergic systems; neurons monoaminergic; orexin neurons; interaction orexin ... See more keywords
Subsecond Ensemble Dynamics of Orexin Neurons Link Sensation and Action.
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers of neurology and neuroscience"
DOI: 10.1159/000514957
Abstract: Hypothalamic hypocretin/orexin neurons have been initially conceptualized as slow, modulatory controllers of behavior. Furthermore, their behavioral effects have been assumed to be a secondary consequence of their impact on arousal. However, cellular-resolution calcium imaging and… read more here.
Keywords: dynamics orexin; subsecond; subsecond ensemble; ensemble dynamics ... See more keywords
The Anti-Narcolepsy Drug Modafinil Reverses Hypoglycemia Unawareness and Normalizes Glucose Sensing of Orexin Neurons in Male Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db22-0639
Abstract: Perifornical hypothalamus (PFH) orexin glucose-inhibited (GI) neurons that facilitate arousal have been implicated in hypoglycemia awareness. Mice lacking orexin exhibit narcolepsy and orexin mediates the effect of the anti-narcolepsy drug, modafinil. Thus, hypoglycemia awareness may… read more here.
Keywords: pfh orexin; orexin; hypoglycemia unawareness; glucose sensitivity ... See more keywords
Neural pathways from hypothalamic orexin neurons to the ventrolateral preoptic area mediate sleep impairments induced by conditioned fear
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1122803
Abstract: Introduction Fear and sleep impairments common co-exist, but the underlying mechanisms remain unclear. Hypothalamic orexinergic neurons are involved in the regulation of sleep-wake and fear expression. The ventrolateral preoptic area (VLPO) is an essential brain… read more here.
Keywords: vlpo; conditioned fear; hypothalamic orexin; orexin neurons ... See more keywords