Effects of selective orexin receptor‐2 and cannabinoid receptor‐1 antagonists on the response of medial prefrontal cortex neurons to tramadol
Sign Up to like & getrecommendations! Published in 2022 at "Synapse"
DOI: 10.1002/syn.22232
Abstract: Tramadol is widely used to control pain in various diseases, but the relevant mechanisms are less known despite the severe risks of abuse. The medial prefrontal cortex (mPFC) is one of the critical centers of… read more here.
Keywords: orexin; orexin receptor; medial prefrontal; receptor ... See more keywords
The dual orexin receptor antagonist almorexant blocks the sleep-disrupting and daytime stimulant effects of methamphetamine in rhesus monkeys.
Sign Up to like & getrecommendations! Published in 2021 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2021.108930
Abstract: BACKGROUND The present study investigated the effects of the dual orexin receptor antagonist (DORA) almorexant, a sleep-modulating drug, on the sleep-disrupting effects of methamphetamine in adult rhesus monkeys. METHODS Monkeys were fitted with primate collars… read more here.
Keywords: effects methamphetamine; methamphetamine; rhesus monkeys; almorexant ... See more keywords
The regulation of orexins and their cognate receptors in two distinct rat models of depression and effects of treatments
Sign Up to like & getrecommendations! Published in 2017 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2017.02.372
Abstract: Introduction Depression has sleep disturbances as a key symptom and recently sleep has been suggested as a new area to optimize treatment in depression. Orexin is produced in the hypothalamus and projected throughout the brain… read more here.
Keywords: orexin; depression; regulation orexins; treatment ... See more keywords
Sex- and Age-dependent Effects of Orexin 1 Receptor Blockade on Open-Field Behavior and Neuronal Activity
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.04.005
Abstract: Adolescence is a sensitive and critical period in brain development where psychiatric disorders such as anxiety, depression and post-traumatic stress disorder are more likely to emerge following a stressful life event. Females are two times… read more here.
Keywords: receptor blockade; field behavior; activity; open field ... See more keywords
Intra-hippocampal administration of orexin receptor antagonists dose-dependently attenuates reinstatement of morphine seeking behavior in extinguished rats
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2018.10.011
Abstract: &NA; It has been shown that the hippocampus plays an essential role in the regulation of reward and memory as indicated by the conditioned place preference (CPP) paradigm. Morphine‐induced CPP is a common method to… read more here.
Keywords: morphine induced; morphine; morphine seeking; induced cpp ... See more keywords
Preclinical assessment of the abuse potential of the orexin receptor antagonist, suvorexant
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2017.03.006
Abstract: &NA; Suvorexant (Belsomra®) is a dual orexin receptor antagonist approved for the treatment of insomnia. Because of its pharmacology within the central nervous system, intended therapeutic indication, and first‐in‐class status, an assessment of suvorexant abuse… read more here.
Keywords: suvorexant; receptor antagonist; pharmacology; assessment ... See more keywords
Design and Synthesis of Orexin 1 Receptor-Selective Agonists.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01773
Abstract: Orexins are a family of neuropeptides that regulate various physiological events, such as sleep/wakefulness as well as emotional and feeding behavior, and that act on two G-protein-coupled receptors, i.e., orexin 1 (OX1R) and orexin 2… read more here.
Keywords: design synthesis; orexin; ox1r selective; synthesis orexin ... See more keywords
The role of orexin-1 receptor signaling in demand for the opioid fentanyl
Sign Up to like & getrecommendations! Published in 2019 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-019-0420-x
Abstract: The orexin system is a potential treatment target for drug addiction. Orexin-1 receptor (OxR1) antagonism reduces demand for cocaine and remifentanil, indicating that orexin-based therapies may reduce demand for many classes of abused drugs. However,… read more here.
Keywords: orexin; opioid fentanyl; oxr1 antagonism; orexin receptor ... See more keywords
Repurposing the dual orexin receptor antagonist suvorexant for the treatment of opioid use disorder: why sleep on this any longer?
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-0619-x
Abstract: In 2017 the US Department of Health and Human Services declared the epidemic of opioid use disorder (OUD) sweeping the nation a public health emergency. Major aspects of OUD management include detoxification, prevention of overdose,… read more here.
Keywords: orexin; use; treatment; drug ... See more keywords
Orexin receptor antagonists reverse aberrant dopamine neuron activity and related behaviors in a rodent model of stress-induced psychosis
Sign Up to like & getrecommendations! Published in 2021 at "Translational Psychiatry"
DOI: 10.1038/s41398-021-01235-8
Abstract: Post-traumatic stress disorder (PTSD) is a prevalent condition affecting approximately 8% of the United States population and 20% of United States combat veterans. In addition to core symptoms of the disorder, up to 64% of… read more here.
Keywords: orexin; activity; dopamine neuron; orexin receptor ... See more keywords
Dual orexin receptor antagonist induces changes in core body temperature in rats after exercise
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-54826-3
Abstract: Hypothalamic orexin neurons are involved in various physiological functions, including thermoregulation. The orexinergic system has been considered as a potent mediator of the exercise response. The present study describes how the antagonization of the orexinergic… read more here.
Keywords: receptor antagonist; orexin; core body; dual orexin ... See more keywords