ORF8 protein of SARS‐CoV‐2 reduces male fertility in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27855
Abstract: As one of the most rapidly evolving proteins of the genus Betacoronavirus, open reading frames (ORF8's) function and potential pathological consequence in vivo are still obscure. In this study, we show that the secretion of… read more here.
Keywords: mice orf8; orf8; fertility; orf8 protein ... See more keywords
A unique view of SARS-CoV-2 through the lens of ORF8 protein
Sign Up to like & getrecommendations! Published in 2021 at "Computers in Biology and Medicine"
DOI: 10.1016/j.compbiomed.2021.104380
Abstract: Immune evasion is one of the unique characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attributed to its ORF8 protein. This protein modulates the adaptive host immunity through down-regulation of MHC-1 (Major Histocompatibility Complex)… read more here.
Keywords: view sars; orf8 protein; unique view; cov lens ... See more keywords
Translational suppression of SARS-COV-2 ORF8 protein mRNA as a Viable therapeutic target against COVID-19: Computational studies on potential roles of isolated compounds from Clerodendrum volubile leaves
Sign Up to like & getrecommendations! Published in 2021 at "Computers in Biology and Medicine"
DOI: 10.1016/j.compbiomed.2021.104964
Abstract: The open reading frame 8 (ORF8) protein of SARS-CoV-2 has been implicated in the onset of cytokine storms, which are responsible for the pathophysiology of COVID-19 infection. The present study investigated the potential of isolated… read more here.
Keywords: orf8 protein; isolated compounds; compounds clerodendrum; volubile leaves ... See more keywords
SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses
Sign Up to like & getrecommendations! Published in 2022 at "International Immunology"
DOI: 10.1093/intimm/dxac044
Abstract: Many patients with severe COVID-19 suffer from pneumonia, and thus elucidation of the mechanisms underlying the development of such severe pneumonia is important. The ORF8 protein is a secreted protein of SARS-CoV-2, whose in vivo… read more here.
Keywords: cov orf8; orf8 protein; viral cytokine; sars cov ... See more keywords
SARS-CoV-2 ORF8 Protein Induces Endoplasmic Reticulum Stress-like Responses and Facilitates Virus Replication by Triggering Calnexin: an Unbiased Study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.00011-23
Abstract: Although SARS-CoV-2 is basically regarded as a homolog of SARS-CoV, with their genomic structure and the majority of their genes being highly homologous, the ORF8 genes of SARS-CoV and SARS-CoV-2 are distinct. The SARS-CoV-2 ORF8… read more here.
Keywords: endoplasmic reticulum; stress; cov orf8; orf8 protein ... See more keywords
An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "PeerJ"
DOI: 10.7717/peerj.13136
Abstract: Open reading frame 8 (ORF8) shows one of the highest levels of variability among accessory proteins in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19). It was previously… read more here.
Keywords: unique truncated; sars cov; truncated orf8; orf8 protein ... See more keywords