Mimicking Human Pathophysiology in Organ‐on‐Chip Devices
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Biosystems"
DOI: 10.1002/adbi.201800109
Abstract: Convergence of life sciences, engineering, and basic sciences has opened new horizons for biologically inspired innovations, and a considerable number of organ‐on‐a‐chip platforms have been developed for mimicking physiological systems of biological organs such as… read more here.
Keywords: chip platforms; mimicking human; organ chip; disease ... See more keywords
Recapitulating pancreatic tumor microenvironment through synergistic use of patient organoids and organ-on-a-chip vasculature.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced functional materials"
DOI: 10.1002/adfm.202000545
Abstract: Tumor progression relies heavily on the interaction between the neoplastic epithelial cells and their surrounding stromal partners. This cell cross-talk affects stromal development, and ultimately the heterogeneity impacts drug efflux and efficacy. To mimic this… read more here.
Keywords: pancreatic tumor; tumor microenvironment; organ chip; tumor ... See more keywords
Continuous pH Monitoring in Organ‐on‐Chip Devices with Single‐Step Fabricated DNA Scaffold Sensors Conjugated Hydrogels and Machine Learning
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202501659
Abstract: In recent years, novel technologies in microfabrication and bioengineering, such as Lab‐on‐Chip and Organ‐on‐Chip, have greatly transformed the research approach to studying complex biological mechanisms. Thanks to these innovations, many up‐to‐date platforms allow scientists to… read more here.
Keywords: real time; time; chip; organ chip ... See more keywords
Organ‐on‐a‐Chip Systems for Women's Health Applications
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201700550
Abstract: Biomedical research, for a long time, has paid little attention to the influence of sex in many areas of study, ranging from molecular and cellular biology to animal models and clinical studies on human subjects.… read more here.
Keywords: chip systems; physiology; women health; organ chip ... See more keywords
Functional Integration of Synthetic Cells into 3D Microfluidic Devices for Artificial Organ‐On‐Chip Technologies
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202303334
Abstract: Microfluidics plays a pivotal role in organ‐on‐chip technologies and in the study of synthetic cells, especially in the development and analysis of artificial cell models. However, approaches that use synthetic cells as integral functional components… read more here.
Keywords: synthetic cells; microfluidic devices; chip; integration synthetic ... See more keywords
Pump‐Less, Recirculating Organ‐on‐Chip (rOoC) Platform to Model the Metabolic Crosstalk between Islets and Liver
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202303785
Abstract: Type 2 diabetes mellitus (T2DM), obesity, and metabolic dysfunction‐associated steatotic liver disease (MASLD) are epidemiologically correlated disorders with a worldwide growing prevalence. While the mechanisms leading to the onset and development of these conditions are… read more here.
Keywords: less recirculating; recirculating organ; chip; organ chip ... See more keywords
Enhanced PDMS Functionalization for Organ‐on‐a‐Chip Platforms Using Ozone and Sulfo‐SANPAH: A Simple Approach for Biomimetic Long‐Term Cell Cultures
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202404686
Abstract: Surface modification of polydimethylsiloxane (PDMS) for organ‐on‐a‐chip (OOC) systems is fundamental for the success of cell physiological assays. Although UV light is commonly used for this purpose, surface chemical modifications are only temporary. To overcome… read more here.
Keywords: sulfo sanpah; surface; cell; using ozone ... See more keywords
Democratizing Organ-On-Chip Technologies With a Modular, Reusable, and Perfusion-Ready Microphysiological System.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202502202
Abstract: Organ‐on‐chip (OOC) technologies, also called microphysiological systems (MPS), offer dynamic microenvironments that improve upon static culture systems, yet widespread adoption has been hindered by fabrication complexity, reliance on polydimethylsiloxane (PDMS), and limited modularity. Here, a… read more here.
Keywords: system; culture; perfusion; chip ... See more keywords
Advances in In vitro Models of Neuromuscular Junction: Focusing on Organ-on-a-chip, Organoids and Biohybrid Robotics.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202211059
Abstract: The neuromuscular junction (NMJ) is a peripheral synaptic connection between presynaptic motor neurons and postsynaptic skeletal muscle fibers that enables muscle contraction and voluntary motor movement. Many traumatic, neurodegenerative and neuroimmunological diseases are classically believed… read more here.
Keywords: neuromuscular junction; organ chip; robotics; organoids biohybrid ... See more keywords
Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ‐on‐a‐Chip
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103241
Abstract: Lymphoid follicles (LFs) are responsible for generation of adaptive immune responses in secondary lymphoid organs and form ectopically during chronic inflammation. A human model of ectopic LF formation will provide a tool to understand LF… read more here.
Keywords: formation; influenza vaccination; ectopic; organ chip ... See more keywords
A pumpless multi‐organ‐on‐a‐chip (MOC) combined with a pharmacokinetic–pharmacodynamic (PK–PD) model
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26087
Abstract: A multi‐organ‐on‐a‐chip (MOC), also known as a human‐on‐a‐chip, aims to simulate whole body response to drugs by connecting microscale cell cultures of multiple tissue types via fluidic channels and reproducing the interaction between them. While… read more here.
Keywords: organ chip; chip moc; model; multi organ ... See more keywords