Mimicking Human Pathophysiology in Organ‐on‐Chip Devices
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Biosystems"
DOI: 10.1002/adbi.201800109
Abstract: Convergence of life sciences, engineering, and basic sciences has opened new horizons for biologically inspired innovations, and a considerable number of organ‐on‐a‐chip platforms have been developed for mimicking physiological systems of biological organs such as… read more here.
Keywords: chip platforms; mimicking human; organ chip; disease ... See more keywords
Recapitulating pancreatic tumor microenvironment through synergistic use of patient organoids and organ-on-a-chip vasculature.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced functional materials"
DOI: 10.1002/adfm.202000545
Abstract: Tumor progression relies heavily on the interaction between the neoplastic epithelial cells and their surrounding stromal partners. This cell cross-talk affects stromal development, and ultimately the heterogeneity impacts drug efflux and efficacy. To mimic this… read more here.
Keywords: pancreatic tumor; tumor microenvironment; organ chip; tumor ... See more keywords
Organ‐on‐a‐Chip Systems for Women's Health Applications
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201700550
Abstract: Biomedical research, for a long time, has paid little attention to the influence of sex in many areas of study, ranging from molecular and cellular biology to animal models and clinical studies on human subjects.… read more here.
Keywords: chip systems; physiology; women health; organ chip ... See more keywords
Advances in In vitro Models of Neuromuscular Junction: Focusing on Organ-on-a-chip, Organoids and Biohybrid Robotics.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202211059
Abstract: The neuromuscular junction (NMJ) is a peripheral synaptic connection between presynaptic motor neurons and postsynaptic skeletal muscle fibers that enables muscle contraction and voluntary motor movement. Many traumatic, neurodegenerative and neuroimmunological diseases are classically believed… read more here.
Keywords: neuromuscular junction; organ chip; robotics; organoids biohybrid ... See more keywords
Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ‐on‐a‐Chip
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103241
Abstract: Lymphoid follicles (LFs) are responsible for generation of adaptive immune responses in secondary lymphoid organs and form ectopically during chronic inflammation. A human model of ectopic LF formation will provide a tool to understand LF… read more here.
Keywords: formation; influenza vaccination; ectopic; organ chip ... See more keywords
A pumpless multi‐organ‐on‐a‐chip (MOC) combined with a pharmacokinetic–pharmacodynamic (PK–PD) model
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26087
Abstract: A multi‐organ‐on‐a‐chip (MOC), also known as a human‐on‐a‐chip, aims to simulate whole body response to drugs by connecting microscale cell cultures of multiple tissue types via fluidic channels and reproducing the interaction between them. While… read more here.
Keywords: organ chip; chip moc; model; multi organ ... See more keywords
Organ-On-A-Chip Models of the Blood-Brain Barrier: Recent Advances and Future Prospects.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202201401
Abstract: The human brain and central nervous system (CNS) present unique challenges in drug development for neurological diseases. One major obstacle is the blood-brain barrier (BBB), which hampers the effective delivery of therapeutic molecules into the… read more here.
Keywords: organ chip; blood brain; brain barrier; brain ... See more keywords
Photo and Soft Lithography for Organ-on-Chip Applications.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1693-2_1
Abstract: Organs-on-Chip devices are generally fabricated by means of photo- and soft lithographic techniques. Photolithography is a process that involves the transfer of a pattern onto a substrate by a selective exposure to light. In particular,… read more here.
Keywords: photo soft; organ chip; lithography organ; soft lithography ... See more keywords
Biomaterials and Culture Systems for Development of Organoid and Organ-on-a-Chip Models
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-020-02498-w
Abstract: The development of novel 3D tissue culture systems has enabled the in vitro study of in vivo processes, thereby overcoming many of the limitations of previous 2D tissue culture systems. Advances in biomaterials, including the… read more here.
Keywords: culture systems; organ chip; discovery; culture ... See more keywords
Progress, obstacles, and limitations in the use of stem cells in organ-on-a-chip models.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2018.06.001
Abstract: In recent years, drug development costs have soared, primarily due to the failure of preclinical animal and cell culture models, which do not directly translate to human physiology. Organ-on-a-chip (OOC) is a burgeoning technology with… read more here.
Keywords: obstacles limitations; ooc models; organ chip; progress obstacles ... See more keywords
High-throughput organ-on-a-chip systems: Current status and remaining challenges
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Biomedical Engineering"
DOI: 10.1016/j.cobme.2018.02.004
Abstract: Abstract Organ-on-a-chip (OoC) systems might be the disruptive technology pharmaceutical industry has been looking for to tackle their ever-increasing R&D costs. First endeavors are well underway to transfer this technology, which was until now used… read more here.
Keywords: status; throughput; organ chip; remaining challenges ... See more keywords