Recent advances in organ-on-chips integrated with bioprinting technologies for drug screening.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203172
Abstract: Currently the demand for more reliable drug screening devices has made scientists and researchers develop novel potential approaches to offer an alternative to animal studies. Organ-on-chips are newly emerged platforms for drug screening and disease… read more here.
Keywords: drug screening; organ chips; advances organ; drug ... See more keywords
Vascularized microfluidic organ-chips for drug screening, disease models and tissue engineering.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2018.03.011
Abstract: Vascularization of micro-tissues in vitro has enabled formation of tissues larger than those limited by diffusion with appropriate nutrient/gas exchange as well as waste elimination. Furthermore, angiocrine signaling from the vasculature may be essential in… read more here.
Keywords: organ chips; micro tissues; vascularized microfluidic; drug ... See more keywords
Automated fabrication of photopatterned gelatin hydrogels for organ-on-chips applications.
Sign Up to like & getrecommendations! Published in 2018 at "Biofabrication"
DOI: 10.1088/1758-5090/aa96de
Abstract: Organ-on-chip platforms aim to improve preclinical models for organ-level responses to novel drug compounds. Heart-on-a-chip assays in particular require tissue engineering techniques that rely on labor-intensive photolithographic fabrication or resolution-limited 3D printing of micropatterned substrates,… read more here.
Keywords: organ chips; hydrogels organ; fabrication; heart chip ... See more keywords
Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics
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DOI: 10.1098/rsob.210333
Abstract: Non-clinical models to study metabolism including animal models and cell assays are often limited in terms of species translatability and predictability of human biology. This field urgently requires a push towards more physiologically accurate recapitulations… read more here.
Keywords: organ chips; disease modelling; multi organ; metabolism ... See more keywords
Microfluidic Organ-Chips and Stem Cell Models in the Fight Against COVID-19
Sign Up to like & getrecommendations! Published in 2023 at "Circulation Research"
DOI: 10.1161/circresaha.122.321877
Abstract: SARS-CoV-2, the virus underlying COVID-19, has now been recognized to cause multiorgan disease with a systemic effect on the host. To effectively combat SARS-CoV-2 and the subsequent development of COVID-19, it is critical to detect,… read more here.
Keywords: cell; organ chips; stem cell; chips stem ... See more keywords