Recent advances in organ-on-chips integrated with bioprinting technologies for drug screening.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203172
Abstract: Currently the demand for more reliable drug screening devices has made scientists and researchers develop novel potential approaches to offer an alternative to animal studies. Organ-on-chips are newly emerged platforms for drug screening and disease… read more here.
Keywords: drug screening; organ chips; advances organ; drug ... See more keywords
Adaptable Manufacturing and Biofabrication of Milliscale Organ Chips With Perfusable Vascular Beds
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Journal"
DOI: 10.1002/biot.202400550
Abstract: Microphysiological systems (MPS) containing perfusable vascular beds unlock the ability to model tissue‐scale elements of vascular physiology and disease in vitro. Access to inexpensive stereolithography (SLA) 3D printers now enables benchtop fabrication of polydimethylsiloxane (PDMS)… read more here.
Keywords: adaptable manufacturing; perfusable vascular; vascular beds; manufacturing biofabrication ... See more keywords
Vascularized microfluidic organ-chips for drug screening, disease models and tissue engineering.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2018.03.011
Abstract: Vascularization of micro-tissues in vitro has enabled formation of tissues larger than those limited by diffusion with appropriate nutrient/gas exchange as well as waste elimination. Furthermore, angiocrine signaling from the vasculature may be essential in… read more here.
Keywords: organ chips; micro tissues; vascularized microfluidic; drug ... See more keywords
Automated fabrication of photopatterned gelatin hydrogels for organ-on-chips applications.
Sign Up to like & getrecommendations! Published in 2018 at "Biofabrication"
DOI: 10.1088/1758-5090/aa96de
Abstract: Organ-on-chip platforms aim to improve preclinical models for organ-level responses to novel drug compounds. Heart-on-a-chip assays in particular require tissue engineering techniques that rely on labor-intensive photolithographic fabrication or resolution-limited 3D printing of micropatterned substrates,… read more here.
Keywords: organ chips; hydrogels organ; fabrication; heart chip ... See more keywords
Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics
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DOI: 10.1098/rsob.210333
Abstract: Non-clinical models to study metabolism including animal models and cell assays are often limited in terms of species translatability and predictability of human biology. This field urgently requires a push towards more physiologically accurate recapitulations… read more here.
Keywords: organ chips; disease modelling; multi organ; metabolism ... See more keywords
Microfluidic Organ-Chips and Stem Cell Models in the Fight Against COVID-19
Sign Up to like & getrecommendations! Published in 2023 at "Circulation Research"
DOI: 10.1161/circresaha.122.321877
Abstract: SARS-CoV-2, the virus underlying COVID-19, has now been recognized to cause multiorgan disease with a systemic effect on the host. To effectively combat SARS-CoV-2 and the subsequent development of COVID-19, it is critical to detect,… read more here.
Keywords: cell; organ chips; stem cell; chips stem ... See more keywords