Analysis of FGF20‐regulated genes in organ of Corti progenitors by translating ribosome affinity purification
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Dynamics"
DOI: 10.1002/dvdy.211
Abstract: Understanding the mechanisms that regulate hair cell (HC) differentiation in the organ of Corti (OC) is essential to designing genetic therapies for hearing loss due to HC loss or damage. We have previously identified Fibroblast… read more here.
Keywords: ribosome affinity; fgf20; organ corti; affinity purification ... See more keywords
Active role of glia‐like supporting cells in the organ of Corti: Membrane proteins and their roles in hearing
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24229
Abstract: The organ of Corti, located in the cochlea in the inner ear, is one of the major sensory organs involved in hearing. The organ of Corti consists of hair cells, glia‐like supporting cells, and the… read more here.
Keywords: membrane proteins; like supporting; organ corti; glia like ... See more keywords
Cochlear amplification and tuning depend on the cellular arrangement within the organ of Corti
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1720979115
Abstract: Significance While the near-crystalline structure of the organ-of-Corti cytoarchitecture in the mammalian cochlea has been known for some time, its functional consequences on hearing remain to be established. The present computational-modeling studies show that individual… read more here.
Keywords: tuning depend; organ corti; cochlear amplification; geometry ... See more keywords
Two passive mechanical conditions modulate power generation by the outer hair cells
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1005701
Abstract: In the mammalian cochlea, small vibrations of the sensory epithelium are amplified due to active electro-mechanical feedback of the outer hair cells. The level of amplification is greater in the base than in the apex… read more here.
Keywords: outer hair; hair cells; organ corti; mechanical conditions ... See more keywords
Pioglitazone Ameliorates Gentamicin Ototoxicity by Affecting the TLR and STAT Pathways in the Early Postnatal Organ of Corti
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.566148
Abstract: Noise trauma, infection, and ototoxic drugs are frequent external causes of hearing loss. With no pharmacological treatments currently available, understanding the mechanisms and pathways leading to auditory hair cell (HC) damage and repair is crucial… read more here.
Keywords: hearing loss; tlr stat; pioglitazone; organ corti ... See more keywords
Distribution of ciliary adaptor proteins tubby and TULP3 in the organ of Corti
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1162937
Abstract: Tubby-like proteins are membrane-associated adaptors that mediate directional trafficking into primary cilia. In inner ear sensory epithelia, cilia—including the hair cell’s kinocilium—play important roles as organizers of polarity, tissue architecture and cellular function. However, auditory… read more here.
Keywords: localization; distribution ciliary; tubby tulp3; hair ... See more keywords
F-Actin Dysplasia Involved in Organ of Corti Deformity in Gjb2 Knockdown Mouse Model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2021.808553
Abstract: Mutations in the GJB2 gene encoding connexin26 (Cx26) protein are one of the most common causes of hereditary deafness. Previous studies have found that different Cx26-null mouse models have severe hearing loss and deformity of… read more here.
Keywords: knockdown mouse; mouse; actin; group ... See more keywords
mTOR Signaling in BDNF-Treated Guinea Pigs after Ototoxic Deafening
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10112935
Abstract: The mammalian target of rapamycin (mTOR) signaling plays a critical role in cell homeostasis, growth and survival. Here, we investigated the localization of the main mTOR signaling proteins in the organ of Corti of normal-hearing… read more here.
Keywords: bdnf treated; mtor signaling; organ corti; guinea pigs ... See more keywords
Thyroxine Regulates the Opening of the Organ of Corti through Affecting P-Cadherin and Acetylated Microtubule
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113339
Abstract: Different serum thyroxine levels may influence the morphology of the inner ear during development. A well-developed organ of Corti (OC) is considered to be critical to the function of hearing. In our study, we treated… read more here.
Keywords: thyroxine regulates; corti affecting; regulates opening; opening organ ... See more keywords