Elucidating the Spectrum of Disease Severity Encompassed by Sepsis.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2021.47888
Abstract: The term sepsis commonly evokes a critically ill patient with multiorgan failure who requires immediate and aggressive lifesaving care. In the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3), sepsis is defined conceptually… read more here.
Keywords: sepsis; peltan colleagues3; clinical criteria; organ dysfunction ... See more keywords
Potential of circulating lncRNA CASC2 as a biomarker in reflecting the inflammatory cytokines, multi‐organ dysfunction, disease severity, and mortality in sepsis patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24569
Abstract: Long noncoding RNA (lncRNA) cancer susceptibility candidate gene 2 (CASC2) inhibits inflammation and multi‐organ dysfunction in various ways. The present study was intended to explore the potency of blood lncRNA CASC2 as a biomarker for… read more here.
Keywords: casc2 biomarker; casc2; organ dysfunction; multi organ ... See more keywords
The mechanism of multiple organ dysfunction syndrome in patients with COVID‐19
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27627
Abstract: In late 2019, an outbreak of coronavirus disease 2019 (COVID‐19) arose, caused by severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2). This disease rapidly became a public health event of international concern. In addition to… read more here.
Keywords: multiple organ; organ dysfunction; syndrome; patients covid ... See more keywords
The Role of ALDH2 in Sepsis and the To-Be-Discovered Mechanisms.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-6260-6_10
Abstract: Sepsis, defined as life-threatening tissue damage and organ dysfunction caused by a dysregulated host response to infection, is a critical disease which imposes global health burden. Sepsis-induced organ dysfunction, including circulatory and cardiac dysfunction, hepatic… read more here.
Keywords: sepsis; dysfunction; septic organ; role ... See more keywords
Organ crosstalk: the potent roles of inflammation and fibrotic changes in the course of organ interactions
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation Research"
DOI: 10.1007/s00011-019-01271-7
Abstract: BackgroundOrgan crosstalk can be defined as the complex and mutual biological communication between distant organs mediated by signaling factors. Normally, crosstalk helps to coordinate and maintain homeostasis, but sudden or chronic dysfunction in any organ… read more here.
Keywords: fibrotic changes; organ crosstalk; organ interactions; crosstalk ... See more keywords
Which organ dysfunction scores to use in children with infection?
Sign Up to like & getrecommendations! Published in 2018 at "Intensive Care Medicine"
DOI: 10.1007/s00134-018-5123-y
Abstract: Initial correspondence from Drs. Leclerc, Duhamel, Leteurtre Dear Editor, We read with interest the paper by Schlapbach et al. comparing the performance of SIRS criteria with measures of organ dysfunction in children with sepsis [1].… read more here.
Keywords: children infection; organ dysfunction; performance; dysfunction scores ... See more keywords
Rhabdomyolysis in a patient complicated with hypopituitarism and multiple organ dysfunction syndrome and the literature review
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Emergency Medicine"
DOI: 10.1016/j.ajem.2018.06.019
Abstract: Introduction Muscular symptoms, including stiffness, myalgia, cramps, and fatigue, are present in the majority of the patients with hypopituitarism, adrenal insufficiency and hypothyroidism, but rhabdomyolysis, the rapid breakdown of skeletal muscle, is a rare manifestation.… read more here.
Keywords: literature; hypopituitarism; rhabdomyolysis; dysfunction syndrome ... See more keywords
Impact of early remote organ dysfunction on long-term survival after liver transplantation.
Sign Up to like & getrecommendations! Published in 2019 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2019.02.016
Abstract: BACKGROUND Attention is focused on graft function although extrahepatic organ dysfunction often occurs. Renal failure, cardiovascular events and sepsis have individually shown a significant impact on short- and long-term outcomes. The aim of the study… read more here.
Keywords: long term; impact; dysfunction; organ dysfunction ... See more keywords
Low-dose hydralazine improves endotoxin-induced coagulopathy and multiple organ dysfunction via its anti-inflammatory and anti-oxidative/nitrosative properties.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173279
Abstract: Coagulopathy is the major cause of organ injury as well as a strong predictor of mortality in septic patients. Systemic inflammatory response and redox imbalance are regarded as the major causes of sepsis-induced coagulopathy. There… read more here.
Keywords: dose hydralazine; low dose; organ dysfunction; induced coagulopathy ... See more keywords
Levosimendan mitigates coagulopathy and organ dysfunction in rats with endotoxemia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Chinese Medical Association"
DOI: 10.1016/j.jcma.2016.12.008
Abstract: Background In patients with severe sepsis, pro‐inflammatory cytokines and subsequent activation of tissue factors trigger a cascade of events that lead to coagulation dysfunction and multiple organ failure. It has been shown that levosimendan has… read more here.
Keywords: group intravenous; infusion; dysfunction; coagulopathy organ ... See more keywords
Days alive and free as an alternative to a mortality outcome in pivotal vasopressor and septic shock trials☆,☆☆,★
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Critical Care"
DOI: 10.1016/j.jcrc.2018.05.003
Abstract: Purpose: RCTs in septic shock negative for mortality may show organ dysfunction benefits. We hypothesized that RCTs in septic shock show significant differences between treatment groups in organ support despite no mortality differences. Methods: RCTs… read more here.
Keywords: rcts septic; daf; septic shock; mortality ... See more keywords