Circular RNAs in Organ Fibrosis.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-1426-1_21
Abstract: Fibrosis refers to a process involving the accumulation of extracellular matrix components. It could happen in chronic organ injury or during the recovery of acute organ injury. The severity of fibrosis interferes with the function… read more here.
Keywords: circular rnas; fibrosis; mechanism; rnas organ ... See more keywords
Pathology and natural history of organ fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2019.09.009
Abstract: Histopathological assessment of fibrosis focusing on morphological patterns provides important information for the management of patients with chronic diseases of the kidney, liver and the lung. This review summarizes key histopathological features of pulmonary, renal… read more here.
Keywords: pathology natural; fibrosis; pathology; natural history ... See more keywords
PDGF in organ fibrosis.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2017.11.008
Abstract: Fibrosis is part of a tissue repair response to injury, defined as increased deposition of extracellular matrix. In some instances, fibrosis is beneficial; however, in the majority of diseases fibrosis is detrimental. Virtually all chronic… read more here.
Keywords: organ fibrosis; pdgf organ; fibrosis;
ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Nature medicine"
DOI: 10.1038/nm.4419
Abstract: Maladaptive wound healing responses to chronic tissue injury result in organ fibrosis. Fibrosis, which entails excessive extracellular matrix (ECM) deposition and tissue remodeling by activated myofibroblasts, leads to loss of proper tissue architecture and organ… read more here.
Keywords: fibrosis; myofibroblast activation; activation; adam10 mediated ... See more keywords
The pathogenesis in organ fibrosis: focus on necroptosis.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of pharmacology"
DOI: 10.1111/bph.15952
Abstract: Fibrosis is a common process of tissue repair response to multiple injuries in all chronic progressive diseases, which featured with excessive deposition of extracellular matrix. Actually fibrosis can occur in all organs and tends to… read more here.
Keywords: necroptosis; cell; organ fibrosis; fibrosis focus ... See more keywords
Targeting CD26/DPP4 in organ fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of pharmacology"
DOI: 10.1111/bph.15967
Abstract: CD26/DPP4 is an exopeptidase that is expressed as a transmembrane protein in many organs but also present in a circulating soluble form. Beyond its enzymatic and co-stimulatory activity, CD26/DPP4 is involved in the pathogenesis of… read more here.
Keywords: organ fibrosis; targeting cd26; dpp4; cd26 dpp4 ... See more keywords
Mechanisms for the Resolution of Organ Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Physiology"
DOI: 10.1152/physiol.00033.2018
Abstract: Fibrosis is a dynamic process with the potential for reversibility and restoration of near-normal tissue architecture and organ function. Herein, we review mechanisms for resolution of organ fibrosis, in particular that involving the lung, with… read more here.
Keywords: fibrosis; physiology; mechanisms resolution; resolution organ ... See more keywords
Macrophage autophagy in macrophage polarization, chronic inflammation and organ fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.946832
Abstract: As the essential regulators of organ fibrosis, macrophages undergo marked phenotypic and functional changes after organ injury. These changes in macrophage phenotype and function can result in maladaptive repair, causing chronic inflammation and the development… read more here.
Keywords: chronic inflammation; organ fibrosis; macrophage autophagy; fibrosis ... See more keywords
PD-1/PD-L1 axis in organ fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1145682
Abstract: Fibrosis is a pathological tissue repair activity in which many myofibroblasts are activated and extracellular matrix are excessively accumulated, leading to the formation of permanent scars and finally organ failure. A variety of organs, including… read more here.
Keywords: organ fibrosis; fibrosis; axis organ;
The Therapeutic Potential of Anticoagulation in Organ Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.866746
Abstract: Fibrosis, also known as organ scarring, describes a pathological stiffening of organs or tissues caused by increased synthesis of extracellular matrix (ECM) components. In the past decades, mounting evidence has accumulated showing that the coagulation… read more here.
Keywords: coagulation; potential anticoagulation; therapeutic potential; anticoagulation ... See more keywords
Indole-Based Small Molecules as Potential Therapeutic Agents for the Treatment of Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.845892
Abstract: Indole alkaloids are widely distributed in nature and have been particularly studied because of their diverse biological activities, such as anti-inflammatory, anti-tumor, anti-bacterial, and anti-oxidant activities. Many kinds of indole alkaloids have been applied to… read more here.
Keywords: indole alkaloids; fibrosis; organ fibrosis; fibrosis treatment ... See more keywords