Drug‐induced organ injury in coronavirus disease 2019 pharmacotherapy: Mechanisms and challenges in differential diagnosis and potential protective strategies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22795
Abstract: The world is currently facing an unprecedented pandemic caused by a newly recognized and highly pathogenic coronavirus disease 2019 (COVID‐19; induced by SARS‐CoV‐2 virus), which is a severe and ongoing threat to global public health.… read more here.
Keywords: drug induced; drug; differential diagnosis; organ injury ... See more keywords
Allogeneic stem cell transplantation recipients requiring intensive care: time is of the essence
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3320-y
Abstract: The benefit of early admission of allogeneic stem cell transplantation (SCT) recipients to the intensive care unit (ICU) as soon as they develop organ injury is unknown. We performed a retrospective study on 92 patients… read more here.
Keywords: admission; time; stem cell; organ injury ... See more keywords
Neuropeptide W Attenuates Oxidative Multi-Organ Injury in Rats Induced with Intra-Abdominal Sepsis.
Sign Up to like & getrecommendations! Published in 2021 at "Inflammation"
DOI: 10.1007/s10753-021-01545-5
Abstract: Sepsis leads to systemic hypotension, disturbed perfusion, inflammation, and tissue toxicity in vital organs. Neuropeptide W (NPW) has modulatory effects in the control of blood pressure and inflammatory processes, implicating a potential beneficial effect against… read more here.
Keywords: sepsis; attenuates oxidative; neuropeptide attenuates; oxidative multi ... See more keywords
Rib fractures and their association With solid organ injury: higher rib fractures have greater significance for solid organ injury screening.
Sign Up to like & getrecommendations! Published in 2017 at "American journal of surgery"
DOI: 10.1016/j.amjsurg.2016.08.002
Abstract: BACKGROUND The purpose of this study was to identify patients with rib injuries who were at risk for solid organ injury. METHODS A retrospective chart review was performed of all blunt trauma patients with rib… read more here.
Keywords: solid organ; organ injury; rib; rib fractures ... See more keywords
It's sooner than you think: Blunt solid organ injury patients are already hypercoagulable upon hospital admission - Results of a bi-institutional, prospective study.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of surgery"
DOI: 10.1016/j.amjsurg.2019.08.024
Abstract: INTRODUCTION The optimal time to initiate venous thromboembolism (VTE) chemoprophylaxis in blunt solid organ injury (BSOI) patients is debated. We hypothesize that 1) BSOI patients are hypercoagulable within 12 h of injury and 2) hypercoagulability dominates… read more here.
Keywords: solid organ; blunt solid; admission; bsoi patients ... See more keywords
Risk of Maternal Morbidity with Increasing Number of Cesareans
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Perinatology"
DOI: 10.1055/s-0038-1673653
Abstract: Objective To estimate the risk of perioperative morbidity with increasing number of cesareans. Study Design We conducted a retrospective cohort study from 2004 to 2010. Patients delivered by cesarean were included. Outcome measures were a… read more here.
Keywords: number cesareans; morbidity increasing; number; increasing number ... See more keywords
Continuous Renal Replacement Therapy for Multiple Organ Injury Induced by Raw Fish Gallbladder Poisoning.
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Therapeutics"
DOI: 10.1097/mjt.0000000000000491
Abstract: gested urinary tract infection, and she was adequately treated. But all cultures (blood, urine, and stool) came negative throughout the hospitalization. Imaging showed extensive mandibular erosion suggestive of surgical debridement versus chronic osteomyelitis. Autoinflammatory, abscess,… read more here.
Keywords: replacement therapy; therapy multiple; continuous renal; organ injury ... See more keywords
Re: ADAM-17: A potential therapeutic target to prevent organ injury after hemorrhagic shock?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000001397
Abstract: To the Editor: P eng et al. showed that, after severe hemorrhagic shock, intestinal intraluminal treatment with tranexamic acid (TXA) reduced intestinal and pulmonary injury associated with a decreased shedding of syndecan-1. Interestingly, the authors… read more here.
Keywords: treatment; organ injury; hemorrhagic shock; shock ... See more keywords
Organ injury scaling 2018 update: Spleen, liver, and kidney.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000002058
Abstract: In 1989, Moore et al. on behalf of the American Association for the Surgery of Trauma (AAST) published the Organ Injury Scale (OIS) for spleen, liver, and kidney.1 This was then updated for spleen and… read more here.
Keywords: liver kidney; organ injury; spleen liver; injury scaling ... See more keywords
High-dimensional proteomics identifies organ injury patterns associated with outcomes in human trauma
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000003880
Abstract: @ShimenaL; @BrachHerzig; @JunruWu1; @SultanAbdelH; @SciosciaPio; @JBonarotiMD; @macky_neal; @jishnu1729; @Jjasonsperrymd; @TheBilliarLab; @trbilliar; #universityofpittsburgh Using comprehensive plasma proteomics, we identified that biomarkers for liver, pulmonary, neurologic, and particularly cardiac injury remained elevated in patients with complex clinical… read more here.
Keywords: damage; tissue specific; injury patterns; injury ... See more keywords
Pseudoaneurysm after High-Grade Penetrating Solid Organ Injury and the Utility of Delayed CT Angiography.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American College of Surgeons"
DOI: 10.1097/xcs.0000000000000730
Abstract: BACKGROUND Leaving an injured solid organ in situ allows preservation of structure function but invites complications from the damaged parenchyma, including pseudoaneurysms (PSAs). Empiric PSA screening after solid organ injury is not yet established, particularly… read more here.
Keywords: high grade; penetrating solid; injury; organ injury ... See more keywords