Aggregation‐Induced Emission (AIE) Photosensitizer Combined Polydopamine Nanomaterials for Organelle‐Targeting Photodynamic and Photothermal Therapy by the Recognition of Sialic Acid
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200242
Abstract: The construction of organelle‐targeting nanomaterials is an effective way to improve tumor imaging and treatment. Here, a new type of composite nanomaterial named as PTTPB is developed. PTTPB is composed of organelle‐targeting aggregation‐induced emission photosensitizer… read more here.
Keywords: induced emission; therapy; aggregation induced; organelle targeting ... See more keywords
Cell organelle targeting of near-infrared croconaine dye controls photothermal outcome.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc02612c
Abstract: Near-infrared croconaine-peptide conjugates that target the cell nucleus promote photothermal induced cell death. In contrast, a croconaine-morpholine conjugate that targets the cell lysosomes promotes lysosome permeabilization without measurable cell phototoxicity. read more here.
Keywords: infrared croconaine; near infrared; organelle targeting; cell organelle ... See more keywords
Dynamic covalent chemistry in live cells for organelle targeting and enhanced photodynamic action
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc04770a
Abstract: Organelle-specific targeting enables increasing the therapeutic index of drugs and localizing probes for better visualization of cellular processes. Current targeting strategies require conjugation of a molecule of interest with organelle-targeting ligands. Here, we propose a… read more here.
Keywords: dynamic covalent; chemistry; hydrazide ligands; live cells ... See more keywords
Spatiotemporally mapping temperature dynamics of lysosomes and mitochondria using cascade organelle-targeting upconversion nanoparticles
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207402119
Abstract: Significance The temperature dynamics inside living cells play a critical role in maintaining the cells’ homeostasis or driving the cells into dysfunction status. Here, we developed temperature-sensitive LysoDots and MitoDots to monitor the in situ… read more here.
Keywords: temperature dynamics; spatiotemporally mapping; mapping temperature; temperature ... See more keywords
An update on cell-penetrating peptides with intracellular organelle targeting
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2022.2034784
Abstract: ABSTRACT Introduction Cell-penetrating peptide (CPP) technologies represent an important strategy to address drug delivery to specific intracellular compartments by covalent conjugation to targeting sequences, potentially enabling strategies to combat most diseases. Areas covered This updated… read more here.
Keywords: organelle targeting; drug delivery; drug; intracellular organelle ... See more keywords
A dual organelle-targeting mechanosensitive probe
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.abn5390
Abstract: Cells are responsive to the mechanical environment, but the methods to detect simultaneously how different organelles react in mechanobiological processes remain largely unexplored. We herein report a dual organelle-targeting fluorescent probe, (E)-1-[3-(diethoxyphosphoryl)propyl]-4-[4-(diethylamino)styryl]pyridin-1-ium bromide (ASP-PE), for… read more here.
Keywords: dual organelle; targeting mechanosensitive; microscopy; mechanosensitive probe ... See more keywords
Multisubcellular organelle-targeting nanoparticle for synergistic chemotherapy and photodynamic/photothermal tumor therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Nanomedicine"
DOI: 10.2217/nnm-2023-0021
Abstract: Background: The subcellular organelle-targeting strategy has attracted wide attention for a variety of reasons, including strong specificity, high accuracy, low dose administration and few side effects. It is an important and challenging task to explore… read more here.
Keywords: synergistic chemotherapy; organelle; chemotherapy photodynamic; organelle targeting ... See more keywords
Aggregation-Induced Emission Luminogens for Enhanced Photodynamic Therapy: From Organelle Targeting to Tumor Targeting
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DOI: 10.3390/bios12111027
Abstract: Photodynamic therapy (PDT) has attracted much attention in the field of anticancer treatment. However, PDT has to face challenges, such as aggregation caused by quenching of reactive oxygen species (ROS), and short 1O2 lifetime, which… read more here.
Keywords: aggregation; induced emission; aggregation induced; organelle targeting ... See more keywords