Rat Organic Anion Transport Protein 1A1 Interacts Directly With Organic Anion Transport Protein 1A4 Facilitating Its Maturation and Trafficking to the Hepatocyte Plasma Membrane
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30772
Abstract: Organic anion transport proteins (OATPs) on the basolateral surface of hepatocytes mediate uptake of a number of drugs and endogenous compounds. Previous studies showed that rat OATP1A1 (rOATP1A1) has a postsynaptic density protein, drosophila disc… read more here.
Keywords: anion transport; plasma membrane; roatp1a1; organic anion ... See more keywords
Inorganic and organic anion sensing by azole family members
Sign Up to like & getrecommendations! Published in 2020 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2020.213369
Abstract: Abstract Anion sensing is one of the most important aspects of chemistry and interest towards anion sensing, directly or indirectly, is evident from publications of the last two decades. Anion sensing is an induced response… read more here.
Keywords: anion; chemistry; inorganic organic; sensing azole ... See more keywords
Organic anion-transporting polypeptide 1a4-mediated heterogeneous distribution of sulforhodamine-101 in rat hepatic lobules.
Sign Up to like & getrecommendations! Published in 2019 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2019.04.001
Abstract: It has been known that organic anion-transporting polypeptides (Oatps) involve hepatic transports several organic anionic compounds and drugs. This study aimed to investigate sulforhodamine-101 (SR-101) distribution in the rat liver, determine the molecules responsible for… read more here.
Keywords: anion transporting; rat; organic anion; rat hepatic ... See more keywords
Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity ‐ The hyperbilirubinemia use case
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.01.002
Abstract: &NA; Hyperbilirubinemia is a pathological condition of excessive accumulation of conjugated or unconjugated bilirubin in blood. It has been associated with neurotoxicity and non‐neural organ dysfunctions, while it can also be a warning of liver… read more here.
Keywords: anion transporting; 1b1 1b3; hyperbilirubinemia; oatp1b1 oatp1b3 ... See more keywords
Renal organic anion transporters in drug–drug interactions and diseases
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.11.001
Abstract: ABSTRACT The kidney plays a vital role in maintaining systemic homeostasis. Active tubular secretion and reabsorption, which are mainly mediated by transporters, is an efficient mechanism for retaining glucose, amino acids, and other nutrients and… read more here.
Keywords: drug interactions; drug; anion transporters; organic anion ... See more keywords
Cellular Uptake of Levocetirizine by Organic Anion Transporter 4.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.03.026
Abstract: The pharmacokinetics of cetirizine, a nonsedating antihistamine, is profoundly affected by transporter-mediated membrane transport in the kidney. In this study, we aimed to investigate the transport mechanism of levocetirizine, the pharmacologically active enantiomer of cetirizine,… read more here.
Keywords: anion transporter; organic anion; levocetirizine; transporter ... See more keywords
Integrative Data Mining, Scaffold Analysis, and Sequential Binary Classification Models for Exploring Ligand Profiles of Hepatic Organic Anion Transporting Polypeptides
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.8b00466
Abstract: Hepatocellular organic anion transporting polypeptides (OATP1B1, OATP1B3, and OATP2B1) are important for proper liver function and the regulation of the drug elimination process. Understanding their roles in different conditions of liver toxicity and cancer requires… read more here.
Keywords: transporting polypeptides; anion transporting; sequential binary; organic anion ... See more keywords
Role of Hepatic Organic Anion Transporter 2 in the Pharmacokinetics of R- and S-Warfarin: In Vitro Studies and Mechanistic Evaluation.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b01108
Abstract: Interindividual variability in warfarin dose requirement demands personalized medicine approaches to balance its therapeutic benefits (anticoagulation) and bleeding risk. Cytochrome P450 2C9 ( CYP2C9) genotype-guided warfarin dosing is recommended in the clinic, given the more… read more here.
Keywords: warfarin; anion transporter; role hepatic; organic anion ... See more keywords
Establishment and Validation of Competitive Counterflow as a Method To Detect Substrates of the Organic Anion Transporting Polypeptide 2B1.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00631
Abstract: The organic anion transporting polypeptide (OATP) 2B1 is ubiquitously expressed and known to facilitate cellular entry. It is widely accepted that transport proteins play a pivotal role in pharmacokinetics. Consequently, testing for interaction with drug… read more here.
Keywords: competitive counterflow; anion transporting; substrates oatp2b1; transporting polypeptide ... See more keywords
(−)-Epigallocatechin-3-gallate Inhibits Human and Rat Renal Organic Anion Transporters
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.0c05586
Abstract: Organic anion transporter 1 (OAT1, SLC22A6) and 3 (OAT3, SLC22A8) are multispecific drug transporters highly expressed on the basolateral membranes of the renal proximal tubules. OAT1 and OAT3 mediate the tubular secretion of clinically significant… read more here.
Keywords: oat1 oat3; epigallocatechin gallate; organic anion; inhibits human ... See more keywords
Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04949-2
Abstract: In vitro data indicates that the kidney proximal tubule (PT) transporters of uremic toxins and solutes (e.g., indoxyl sulfate, p-cresol sulfate, kynurenine, creatinine, urate) include two “drug” transporters of the organic anion transporter (OAT) family:… read more here.
Keywords: uremic toxins; oat1 oat3; handling uremic; toxins solutes ... See more keywords