Genetic and Epigenetic Regulation of Organic Cation Transporters.
Sign Up to like & getrecommendations! Published in 2021 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2021_450
Abstract: Organic cation transporters (OCTs) of the solute carrier family (SLC) 22 are the subject of intensive research because they mediate the transport of many clinically-relevant drugs such as the antidiabetic agent metformin, the opioid tramadol,… read more here.
Keywords: epigenetic regulation; organic cation; oct2 oct3; cation transporters ... See more keywords
Carnitine/Organic Cation Transporter OCTN1 Negatively Regulates Activation in Murine Cultured Microglial Cells
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2350-5
Abstract: Brain immune cells, i.e., microglia, play an important role in the maintenance of brain homeostasis, whereas chronic overactivation of microglia is involved in the development of various neurodegenerative disorders. Therefore, the regulation of microglial activation… read more here.
Keywords: cation transporter; transporter octn1; organic cation; carnitine organic ... See more keywords
High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical research"
DOI: 10.1007/s11095-022-03171-8
Abstract: INTRODUCTION The organic cation transporter 3 (OCT3, SLC22A3) is ubiquitously expressed and interacts with a wide array of compounds including endogenous molecules, environmental toxins and prescription drugs. Understudied as a determinant of pharmacokinetics and pharmacodynamics,… read more here.
Keywords: drug; prescription; organic cation; cation transporter ... See more keywords
Cellular uptake properties of lamotrigine in human placental cell lines: Investigation of involvement of organic cation transporters (SLC22A1-5).
Sign Up to like & getrecommendations! Published in 2020 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2020.01.005
Abstract: Lamotrigine (LTG) is an important antiepileptic drug for the treatment of seizures in pregnant women with epilepsy. However, it is not known if the transport of LTG into placental cells occurs via a carrier-mediated pathway.… read more here.
Keywords: cell lines; organic cation; uptake properties; placental cell ... See more keywords
Key role of organic cation transporter 2 for the nephrotoxicity effect of triptolide in rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105959
Abstract: Tripterygium wilfordii Hook. F. (TwHF), a traditional Chinese Medicine, is effective in treating rheumatoid arthritis (RA), but its severe nephrotoxicity limits its extensive application. The nephrotoxic mechanism of Triptolide (TP), the main pharmacological and toxic… read more here.
Keywords: cation transporter; rheumatoid arthritis; arthritis; organic cation ... See more keywords
A proton-coupled organic cation antiporter is involved in the blood-brain barrier transport of aconitum alkaloids.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.112581
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE The herbs of Aconitum are the essential traditional Chinese medicine and have played an indispensable role in many Asian countries for thousands of years to treat critical illnesses, and chronic, stubborn diseases. However,… read more here.
Keywords: proton coupled; blood brain; brain; organic cation ... See more keywords
Organic Cation Modulation Triggered Second Harmonic Response in Manganese Halides with Bright Fluorescence.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c01796
Abstract: Zero-dimensional (0D) hybrid manganese halides have been recently synthesized and exhibited rich functional properties including fluorescence, ferroelectrics, and ferromagnetism. However, few studies on second-harmonic generation (SHG) behaviors of manganese halide crystals have been reported, presumably… read more here.
Keywords: organic cation; second harmonic; cation modulation; manganese halides ... See more keywords
Selective Inhibition of Organic Cation Transporter 1 by Benzoylpaeoniflorin Attenuates Hepatic Lipid Accumulation through AMPK Activation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00927
Abstract: Organic cation transporter 1 (OCT1) is a liver-specific transporter and plays an essential role in drug disposition and hepatic lipid metabolism. Therefore, inhibition of OCT1 may not only lead to drug-drug interactions but also represent… read more here.
Keywords: hepatic lipid; transporter; lipid accumulation; cation transporter ... See more keywords
Neurochemical characterization of mouse dorsal root ganglion neurons expressing organic cation transporter 2
Sign Up to like & getrecommendations! Published in 2020 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001416
Abstract: Organic cation transporters (OCTs) are poly-specific carriers for endogenous and exogenous cationic compounds. These are widely distributed in the nervous system and mediate neuronal activities. As antineoplastic cationic drugs accumulate in the dorsal root ganglion… read more here.
Keywords: root ganglion; organic cation; dorsal root; dorsal ... See more keywords
Inorganic vs organic cation ionic liquids and their solutions with alkali metal containing ionic liquids
Sign Up to like & getrecommendations! Published in 2017 at "Journal of The Electrochemical Society"
DOI: 10.1149/2.1331702jes
Abstract: The burgeoning field of ionic liquids (in the current sense of low-melting liquids (Tm < 100◦C) consisting only of ions), has been dominated by liquids containing organic molecular cations. Although a few cases of all-inorganic… read more here.
Keywords: inorganic ionic; cation; inorganic organic; low melting ... See more keywords
Effects of the genetic variants of organic cation transporters 1 and 3 on the pharmacokinetics of metformin in Jordanians
Sign Up to like & getrecommendations! Published in 2017 at "Drug Metabolism and Personalized Therapy"
DOI: 10.1515/dmpt-2017-0019
Abstract: Abstract Background: Human response to the antidiabetic metformin is influenced by some factors, such as genetic variants in the SLC22A genes. This study aimed to determine the frequency of main SLC22A1 and SLC22A3 genetic variants… read more here.
Keywords: genetic variants; metformin; effects genetic; study ... See more keywords