The spatial organization of cGAS-TREX1 interactions.
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DOI: 10.1016/j.devcel.2021.03.016
Abstract: Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms to avoid autoimmunity. A key factor is the exonuclease TREX1, which antagonizes DNA-mediated activation of cGAS. Two studies, by Mohr et al. (2021)… read more here.
Keywords: spatial organization; cgas; trex1; trex1 interactions ... See more keywords