Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.03.015
Abstract: SUMMARY Neurodegenerative diseases commonly involve the disruption of circadian rhythms. Studies indicate that mutant Huntingtin (mHtt), the cause of Huntington’s disease (HD), disrupts circadian rhythms often before motor symptoms are evident. Yet little is known… read more here.
Keywords: organizing protein; aggregation toxicity; heat shock; circadian clocks ... See more keywords
Biotic and abiotic stress induces the expression of Hsp70/90 organizing protein gene in silkworm, Bombyx mori.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.12.067
Abstract: The heat shock 70/90 organizing protein is one of the stress-induced proteins and has extensively been studied in mammals. It mediates the interaction of Hsp70 and Hsp 90 as cochaperone and also implicated in infection-related… read more here.
Keywords: organizing protein; silkworm bombyx; stress; gene silkworm ... See more keywords