Organocatalytic Atroposelective Synthesis of Isoquinolines via Dynamic Kinetic Resolution.
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DOI: 10.1021/acs.orglett.1c04330
Abstract: Herein, a highly enantioselective Pictet-Spengler reaction for the synthesis of axially chiral tetrahydroisoquinolines via dynamic kinetic resolution is described. Chiral phosphoric acids catalyze cyclization to yield single regioisomeric isoquinolines with excellent enantioselectivities around the C-C… read more here.
Keywords: via dynamic; organocatalytic atroposelective; synthesis; dynamic kinetic ... See more keywords