Stereodivergent Synthesis of All Stereoisomers of 2,3-Disubstituted δ-Lactam Derivatives via Organocatalytic Cascade Reactions and Base-Induced Epimerization.
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DOI: 10.1021/acs.orglett.3c03861
Abstract: A protocol was developed to achieve stereodivergent synthesis of stereoisomers of δ-lactam bearing vicinal chiral centers. Organocatalytic cascade reactions were employed to produce the target products as the kinetic products, which exhibited remarkable enantioselectivities. In… read more here.
Keywords: synthesis stereoisomers; stereodivergent synthesis; organocatalytic cascade; cascade reactions ... See more keywords
Asymmetric Organocatalytic Cascade Synthesis of Tetrahydrofuranyl Spirooxindoles
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DOI: 10.1055/s-0036-1590918
Abstract: An enantio- and regioselective organocatalytic cascade starting from isatin has been disclosed to construct tetrahydrofuranyl spirooxindoles in high yields and stereoselectivities. Also, a triple cascade leading to the pentacyclic compound with two quaternary and a… read more here.
Keywords: cascade; organocatalytic cascade; cascade synthesis; synthesis tetrahydro ... See more keywords