Three-dimensional testicular organoid: a novel tool for the study of human spermatogenesis and gonadotoxicity in vitro†
Sign Up to like & getrecommendations! Published in 2017 at "Biology of Reproduction"
DOI: 10.1095/biolreprod.116.143446
Abstract: Abstract Existing methods for evaluating the potential gonadotoxicity of environmental agents and pharmaceutical compounds rely heavily on animal studies. The current gold standard in vivo functional assays in animals are limited in their human predictive… read more here.
Keywords: three dimensional; testicular organoid; gonadotoxicity; tool ... See more keywords
AB0189 3d skin organoid mimicking systemic sclerosis generated by patient-derived induced pluripotent stem cells: ‘disease in a dish’ and development of animal model
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.4502
Abstract: Background Systemic sclerosis (SSc) is a rare autoimmune disease characterised by vasculopathy and fibrosis of various organs including skin. Although SSc has high morbidity and mortality, evidences for disease modifying treatment are still lacking due… read more here.
Keywords: skin organoid; ssc derived; model; stem cells ... See more keywords
Organoid factory: The recent role of the human induced pluripotent stem cells (hiPSCs) in precision medicine
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1059579
Abstract: During the last decades, hiPSC-derived organoids have been extensively studied and used as in vitro models for several applications among which research studies. They can be considered as organ and tissue prototypes, especially for those… read more here.
Keywords: role; hipsc derived; personalized medicine; drug ... See more keywords
Large-scale organoid study suggests effects of trisomy 21 on early fetal neurodevelopment are more subtle than variability between isogenic lines and experiments
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.972201
Abstract: This study examines cortical organoids generated from a panel of isogenic trisomic and disomic iPSC lines (subclones) as a model of early fetal brain development in Down syndrome (DS). An initial experiment comparing organoids from… read more here.
Keywords: early fetal; isogenic lines; variability; study ... See more keywords
Development of Patient-Derived Preclinical Platform for Metastatic Pancreatic Cancer: PDOX and a Subsequent Organoid Model System Using Percutaneous Biopsy Samples
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00875
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignant tumor and more than 50% patients are diagnosed at metastatic stage. The preclinical model systems that reflect the genetic heterogeneity of metastatic tumors are urgently needed… read more here.
Keywords: model; pdox; cancer; organoid ... See more keywords
Metabolic Activation of Benzo[a]pyrene by Human Tissue Organoid Cultures
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010606
Abstract: Organoids are 3D cultures that to some extent reproduce the structure, composition and function of the mammalian tissues from which they derive, thereby creating in vitro systems with more in vivo-like characteristics than 2D monocultures.… read more here.
Keywords: benzo pyrene; benzo; bap; activation ... See more keywords