Rational Design and Organoid‐Based Evaluation of a Cocktail CAR‐γδ T Cell Therapy for Heterogeneous Glioblastoma
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202501772
Abstract: Various challenges, including tumor heterogeneity and inadequate T cell infiltration, impede the progress of chimeric antigen receptor T cell (CAR‐T) therapy for glioblastoma (GBM). To address these obstacles, a multiple step strategy is designed. Initially,… read more here.
Keywords: cocktail car; organoid based; car; cell ... See more keywords
Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109568
Abstract: Malignant rhabdoid tumors (MRTs) represent one of the most aggressive childhood malignancies. No effective treatment options are available, and prognosis is, therefore, dismal. Previous studies have demonstrated that tumor organoids capture the heterogeneity of patient… read more here.
Keywords: rhabdoid tumors; malignant rhabdoid; drug screening; organoid based ... See more keywords
Put to the test: Organoid-based testing becomes a clinical tool
Sign Up to like & getrecommendations! Published in 2017 at "Nature Medicine"
DOI: 10.1038/nm0717-796
Abstract: 796 VOLUME 23 | NUMBER 7 | JULY 2017 NATURE MEDICINE grown into rectal organoids1. These balls of cells, similarly to the human rectum, contain a hollow space known as a lumen in between two… read more here.
Keywords: medicine; cystic fibrosis; test organoid; put test ... See more keywords
Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-55076-2
Abstract: The lack of a robust system to reproducibly propagate HRV-C, a family of viruses refractory to cultivation in standard cell lines, has substantially hindered our understanding of this common respiratory pathogen. We sought to develop… read more here.
Keywords: hrv; organoid based; respiratory organoids; virus ... See more keywords
Abstract A16: Patient-derived organoid-based models for endometrial cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.camodels2020-a16
Abstract: Introduction: Comprehensive profiling of tumors using omics technologies has improved our understanding of the molecular landscape of endometrial cancer (EC), building the foundation for precision medicine. However, targeted therapies that show promise in preclinical research… read more here.
Keywords: endometrial cancer; cancer; organoid based; derived organoid ... See more keywords
The potential of organoids in toxicologic pathology: Histopathological and immunohistochemical evaluation of a mouse normal tissue-derived organoid-based carcinogenesis model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Toxicologic Pathology"
DOI: 10.1293/tox.2022-0021
Abstract: Recently, we introduced an organoid-based chemical carcinogenesis model using mouse normal tissue-derived organoids. In the present review article, the histopathological and immunohistochemical characteristics of mouse normal tissue-derived organoids and tumors derived from these organoids after… read more here.
Keywords: organoid based; normal tissue; pathology; carcinogenesis ... See more keywords
A novel deep learning segmentation model for organoid-based drug screening
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1080273
Abstract: Organoids are self-organized three-dimensional in vitro cell cultures derived from stem cells. They can recapitulate organ development, tissue regeneration, and disease progression and, hence, have broad applications in drug discovery. However, the lack of effective… read more here.
Keywords: drug screening; organoid based; deep learning; model ... See more keywords
Stem Cells and Organoids: A Paradigm Shift in Preclinical Models Toward Personalized Medicine
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceuticals"
DOI: 10.3390/ph18070992
Abstract: Background/Objectives: Human pluripotent stem cells (hPSCs) and organoid technologies are transforming pharmaceutical research by providing models that more accurately reflect human physiology, genetic variability, and disease mechanisms. This review aims to assess how these systems… read more here.
Keywords: organoids paradigm; organoid based; drug; stem cells ... See more keywords