Testing Susceptibility of Patient-Derived Organoid Cultures to Therapies: Pharmacotyping.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7847-2_19
Abstract: Increasingly, patient models of disease are being utilized to facilitate precision medicine approaches through molecular characterization or direct chemotherapeutic testing. Organoids, 3-dimensional (3D) cultures of neoplastic cells derived from primary tumor specimens, represent an ideal… read more here.
Keywords: susceptibility patient; organoid cultures; protocol; testing susceptibility ... See more keywords
Organoid Cultures for Assessing Intestinal Epithelial Differentiation and Function in Response to Type-2 Inflammation.
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DOI: 10.1007/978-1-4939-7896-0_29
Abstract: During helminth infection of the gastrointestinal tract, a complex Type-2 inflammatory response involving immunological and mucosal components is mounted to clear the infection and reestablish a physiologically normal state. This response is characterized by the… read more here.
Keywords: response; type inflammation; organoid cultures; inflammation ... See more keywords
The Next MacGyver: A Platform to Study Intestinal Organoids Using High-Throughput Computer-Driven Microinjection
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2018.06.010
Abstract: he complex microbial community that lives in the Tcolon plays an important role in diverse biological pathways and is linked to many diseases including inflammatory bowel disease, obesity, and cancer. Defining how microbial interactions influence… read more here.
Keywords: throughput; gastroenterology; organoid cultures; microinjection ... See more keywords
Establishment of Epithelial Inflammatory Injury Model Using Intestinal Organoid Cultures
Sign Up to like & getrecommendations! Published in 2023 at "Stem Cells International"
DOI: 10.1155/2023/3328655
Abstract: Intestinal epithelial dysfunction is critical in the development of inflammatory bowel disease (IBD). However, most cellular experiments related to epithelial barrier studies in IBD have been based on tumor cell line that lack a variety… read more here.
Keywords: epithelial inflammatory; inflammatory injury; intestinal organoid; model ... See more keywords
Abstract IA09: Tumor organoid cultures as a platform for functional genomics
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.camodels2020-ia09
Abstract: In an era of genomics-guided precision medicine, there is an increasing need for models that reflect the hallmarks of cancer and the molecular diversity of patient tumors. New cell culturing methods are transforming our ability… read more here.
Keywords: cultures platform; tumor organoid; functional genomics; organoid cultures ... See more keywords
Low-Level Mouse DNA in Conditioned Medium Generates False Positive Cross-Species Contamination Results in Human Organoid Cultures
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.587107
Abstract: Cell line authentication is critical for preventing the use of mixed or misidentified cell lines in research. Current efforts include short tandem repeat (STR) analysis and PCR-based assays to detect mixed species cultures. Using PCR… read more here.
Keywords: mouse dna; dna; human organoid; organoid cultures ... See more keywords
Organoid Cultures In Silico: Tools or Toys?
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineering"
DOI: 10.3390/bioengineering10010050
Abstract: The implementation of stem-cell-based organoid culture more than ten years ago started a development that created new avenues for diagnostic analyses and regenerative medicine. In parallel, computational modelling groups realized the potential of this culture… read more here.
Keywords: cell; medicine; tools toys; cultures silico ... See more keywords
From 2D to 3D: Development of Monolayer Dopaminergic Neuronal and Midbrain Organoid Cultures for Parkinson’s Disease Modeling and Regenerative Therapy
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032523
Abstract: Parkinson’s Disease (PD) is a prevalent neurodegenerative disorder that is characterized pathologically by the loss of A9-specific dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of the midbrain. Despite intensive research, the etiology… read more here.
Keywords: disease; development; parkinson disease; therapy ... See more keywords