Human pancreatic tumour organoid‐derived factors enhance myogenic differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12917
Abstract: Most patients with pancreatic cancer develop cachexia, which is characterized by progressive muscle loss. The mechanisms underlying muscle loss in cancer cachexia remain elusive. Pancreatic tumour organoids are 3D cell culture models that retain key… read more here.
Keywords: tumour organoid; pancreatic tumour; muscle; tumour ... See more keywords
Development of a protocol for maintaining viability while shipping organoid‐derived retinal tissue
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2997
Abstract: Retinal organoid technology enables generation of an inexhaustible supply of three‐dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications. The high similarity of organoid‐derived retinal tissue and transplantable human fetal retina… read more here.
Keywords: medicine; retinal tissue; organoid derived; tissue ... See more keywords
3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07594-z
Abstract: The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming interdigitating foot processes with intervening slit diaphragms, disruption in which results in proteinuria. Studies into human podocytopathies to date have employed… read more here.
Keywords: organoid derived; disease modelling; podocyte; cell ... See more keywords
Variable susceptibility of intestinal organoid–derived monolayers to SARS-CoV-2 infection
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1101/2021.07.16.452680
Abstract: Gastrointestinal effects associated with COVID-19 are highly variable for reasons that are not understood. In this study, we used intestinal organoid-derived cultures differentiated from primary human specimens as a model to examine inter-individual variability. Infection… read more here.
Keywords: derived monolayers; intestinal organoid; infection; organoid derived ... See more keywords
Human duodenal organoid‐derived monolayers serve as a suitable barrier model for duodenal tissue
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14804
Abstract: Usually, duodenal barriers are investigated using intestinal cell lines like Caco‐2, which in contrast to native tissue are limited in cell‐type representation. Organoids can consist of all intestinal cell types and are supposed to better… read more here.
Keywords: cell; derived monolayers; barrier; duodenal tissue ... See more keywords
A Versatile Human Intestinal Organoid-Derived Epithelial Monolayer Model for the Study of Enteric Pathogens
Sign Up to like & getrecommendations! Published in 2021 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00003-21
Abstract: While traditional laboratory techniques and animal models have provided valuable knowledge in discerning virulence mechanisms of enteric pathogens, the complexity of the human gastrointestinal tract has hindered our understanding of physiologically relevant, human-specific interactions and,… read more here.
Keywords: human intestinal; model; human specific; organoid derived ... See more keywords
Theratyping of the Rare CFTR Variants E193K and R334W in Rectal Organoid-Derived Epithelial Monolayers
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12040632
Abstract: Background: The effect of presently available CFTR modulator combinations, such as elexacaftor (ELX), tezacaftor (TEZ), and ivacaftor (IVA), on rare CFTR alleles is often unknown. Several assays have been developed, such as forskolin-induced swelling (FIS),… read more here.
Keywords: medicine; iva; organoid derived; epithelial monolayers ... See more keywords