Establishment of an in vitro organoid model of dermal papilla of human hair follicle
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26853
Abstract: Human hair dermal papilla (DP) cells are specialized mesenchymal cells that play a pivotal role in hair regeneration and hair cycle activation. The current study aimed to first develop three‐dimensional (3D) DP spheroids (DPS) with… read more here.
Keywords: human hair; hair; vitro organoid; model ... See more keywords
A mouse pancreatic organoid model to compare PD-L1 blocking antibodies
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2139886
Abstract: ABSTRACT Immune checkpoint inhibitors (ICIs) have changed the therapeutic landscape for cancer patients, but diabetes, a rare, severe immune-related endocrinopathy, is linked to ICI therapy. It is unclear whether glycosylation of ICIs may play a… read more here.
Keywords: blocking antibodies; pancreatic organoid; mouse pancreatic; organoid model ... See more keywords
An organoid model derived from human adipose stem/progenitor cells to study adipose tissue physiology
Sign Up to like & getrecommendations! Published in 2022 at "Adipocyte"
DOI: 10.1080/21623945.2022.2044601
Abstract: ABSTRACT We established a functional adipose organoid model system for human adipose stem/progenitor cells (ASCs) isolated from white adipose tissue (WAT). ASCs were forced to self-aggregate by a hanging-drop technique. Afterwards, spheroids were transferred into… read more here.
Keywords: stem progenitor; organoid model; physiology; human adipose ... See more keywords
Preferential uptake of SARS-CoV-2 by pericytes potentiates vascular damage and permeability in an organoid model of the microvasculature
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvac097
Abstract: Abstract Aims Thrombotic complications and vasculopathy have been extensively associated with severe COVID-19 infection; however, the mechanisms inducing endotheliitis and the disruption of endothelial integrity in the microcirculation are poorly understood. We hypothesized that within… read more here.
Keywords: damage; infection; organoid model; permeability ... See more keywords
Newly Established Patient-derived Organoid Model of Intracranial Meningioma.
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-oncology"
DOI: 10.1093/neuonc/noab155
Abstract: BACKGROUND Recent comprehensive studies have revealed several molecular alterations that are frequently found in meningiomas. However, effective treatment reagents targeting specific molecular alterations have not yet been identified because of the limited number of representative… read more here.
Keywords: foxm1; proliferation; organoid model; meningioma ... See more keywords
Abstract 3870: Validation of a canine intestinal organoid model as a preclinical screen to assess GI toxicity in novel oncology drug development
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3870
Abstract: Gastrointestinal (GI) toxicity is a common and often severe dose-limiting side effect of chemotherapy. Symptoms include diarrhea, dehydration and ulceration leading to increased susceptibility to infection, due in part to the damage or loss of… read more here.
Keywords: toxicity; organoid model; novel oncology; intestinal organoid ... See more keywords
Evaluation of B7-H3 Targeted Immunotherapy in a 3D Organoid Model of Craniopharyngioma
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DOI: 10.3390/biom12121744
Abstract: A craniopharyngioma (CP) is a rare epithelial tumor of the sellar and parasellar region. CPs are difficult to treat due to their anatomical proximity to critical nervous structures, which limits the ability of the surgeon… read more here.
Keywords: targeted immunotherapy; immunotherapy organoid; evaluation targeted; organoid model ... See more keywords