Establishment of an in vitro organoid model of dermal papilla of human hair follicle
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26853
Abstract: Human hair dermal papilla (DP) cells are specialized mesenchymal cells that play a pivotal role in hair regeneration and hair cycle activation. The current study aimed to first develop three‐dimensional (3D) DP spheroids (DPS) with… read more here.
Keywords: human hair; hair; vitro organoid; model ... See more keywords
Matrix directs trophoblast differentiation in a bioprinted organoid model of early placental development
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-62996-0
Abstract: Trophoblast organoids can provide crucial insights into mechanisms of placentation, however their potential is limited by highly variable extracellular matrices unable to reflect in vivo tissues. Here, we present a bioprinted placental organoid model, generated… read more here.
Keywords: differentiation; placenta; model; trophoblast ... See more keywords
Validation of hyperthermia as an enhancer of chemotherapeutic efficacy: insights from a bladder cancer organoid model
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Hyperthermia"
DOI: 10.1080/02656736.2024.2316085
Abstract: Abstract Objective This study aimed to evaluate the combined efficacy of hyperthermia and chemotherapy using a bladder cancer organoid model and to explore hyperthermia-related molecular pathways. Method Tumor organoids were generated by embedding RT4 bladder… read more here.
Keywords: bladder cancer; organoid model; cancer organoid; hyperthermia ... See more keywords
A mouse pancreatic organoid model to compare PD-L1 blocking antibodies
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2139886
Abstract: ABSTRACT Immune checkpoint inhibitors (ICIs) have changed the therapeutic landscape for cancer patients, but diabetes, a rare, severe immune-related endocrinopathy, is linked to ICI therapy. It is unclear whether glycosylation of ICIs may play a… read more here.
Keywords: blocking antibodies; pancreatic organoid; mouse pancreatic; organoid model ... See more keywords
An organoid model derived from human adipose stem/progenitor cells to study adipose tissue physiology
Sign Up to like & getrecommendations! Published in 2022 at "Adipocyte"
DOI: 10.1080/21623945.2022.2044601
Abstract: ABSTRACT We established a functional adipose organoid model system for human adipose stem/progenitor cells (ASCs) isolated from white adipose tissue (WAT). ASCs were forced to self-aggregate by a hanging-drop technique. Afterwards, spheroids were transferred into… read more here.
Keywords: stem progenitor; organoid model; physiology; human adipose ... See more keywords
Preferential uptake of SARS-CoV-2 by pericytes potentiates vascular damage and permeability in an organoid model of the microvasculature
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvac097
Abstract: Abstract Aims Thrombotic complications and vasculopathy have been extensively associated with severe COVID-19 infection; however, the mechanisms inducing endotheliitis and the disruption of endothelial integrity in the microcirculation are poorly understood. We hypothesized that within… read more here.
Keywords: damage; infection; organoid model; permeability ... See more keywords
Newly Established Patient-derived Organoid Model of Intracranial Meningioma.
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-oncology"
DOI: 10.1093/neuonc/noab155
Abstract: BACKGROUND Recent comprehensive studies have revealed several molecular alterations that are frequently found in meningiomas. However, effective treatment reagents targeting specific molecular alterations have not yet been identified because of the limited number of representative… read more here.
Keywords: foxm1; proliferation; organoid model; meningioma ... See more keywords
NFS-22. INVESTIGATING MALIGNANT TRANSFORMATION IN NF1 PEDIATRIC GLIOMAS USING AN IPSCS-DERIVED CEREBRAL ORGANOID MODEL
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae064.580
Abstract: Abstract BACKGROUND Neurofibromatosis Type 1 (NF1) is an autosomal dominant tumor predisposition syndrome affecting 1 in 3000 children around the world. Although NF1 inactivation is recognized as the cause of low-grade glioma (LGG) development, little… read more here.
Keywords: gliomas; malignant transformation; transformation nf1; organoid model ... See more keywords
Specialized signaling centers direct cell fate and spatial organization in a mesodermal organoid model
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.ady7682
Abstract: Specialized signaling centers orchestrate robust development and regeneration. Limb morphogenesis, for instance, requires interactions between the mesoderm and the signaling center apical-ectodermal ridge (AER), whose properties and role in cell fate decisions have remained challenging… read more here.
Keywords: signaling centers; specialized signaling; cell; cell fate ... See more keywords
Abstract 3870: Validation of a canine intestinal organoid model as a preclinical screen to assess GI toxicity in novel oncology drug development
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3870
Abstract: Gastrointestinal (GI) toxicity is a common and often severe dose-limiting side effect of chemotherapy. Symptoms include diarrhea, dehydration and ulceration leading to increased susceptibility to infection, due in part to the damage or loss of… read more here.
Keywords: toxicity; organoid model; novel oncology; intestinal organoid ... See more keywords
Co-culture of human AT2 cells with fibroblasts reveals a MUC5B phenotype: insights from an organoid model
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Medicine"
DOI: 10.1186/s10020-024-00990-w
Abstract: Impaired interaction of fibroblasts with pneumocytes contributes to the progression of chronic lung disease such as idiopathic pulmonary fibrosis (IPF). Mucin 5B (MUC5B) is associated with IPF. Here we analyzed the interaction of primary fibroblasts… read more here.
Keywords: culture; at2 cells; culture human; muc5b ... See more keywords