Patient‐derived organoid models help define personalized management of gastrointestinal cancer
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Surgery"
DOI: 10.1002/bjs.10726
Abstract: The prognosis of patients with different gastrointestinal cancers varies widely. Despite advances in treatment strategies, such as extensive resections and the addition of new drugs to chemotherapy regimens, conventional treatment strategies have failed to improve… read more here.
Keywords: organoid models; models help; cancer; derived organoid ... See more keywords
Newly Established Patient-derived Organoid Model of Intracranial Meningioma.
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-oncology"
DOI: 10.1093/neuonc/noab155
Abstract: BACKGROUND Recent comprehensive studies have revealed several molecular alterations that are frequently found in meningiomas. However, effective treatment reagents targeting specific molecular alterations have not yet been identified because of the limited number of representative… read more here.
Keywords: foxm1; proliferation; organoid model; meningioma ... See more keywords
Abstract 4755: Screening non-small cell lung cancer organoids with epigenetic probes
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4755
Abstract: Introduction: NSCLC is associated with high cancer-related mortality worldwide. Epigenetic modifications at the chromatin level have widely been linked to carcinogenesis. Epigenetic regulation not only contributes to the development of cancer, but it may also… read more here.
Keywords: cell; organoid models; non small; screening non ... See more keywords
Abstract 5776: Advancing a screening platform with panels of patient-derived organoid models for drug discovery and development
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5776
Abstract: High-throughput screening (HTS) offers the potential to rapidly evaluate the activities of anticancer single agents and combinations in many types of cell-based tumor models; however, successful translation of the findings to patients requires tumor models… read more here.
Keywords: oncology; organoid models; derived organoid; patient derived ... See more keywords
Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202216001
Abstract: Rhabdomyosarcomas (RMS) are mesenchyme-derived tumors and the most common childhood soft tissue sarcomas. Treatment is intense, with a nevertheless poor prognosis for high-risk patients. Discovery of new therapies would benefit from additional preclinical models. Here… read more here.
Keywords: organoid models; models recapitulate; recapitulate rhabdomyosarcoma; tumor organoid ... See more keywords
Studying Kidney Diseases Using Organoid Models
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.845401
Abstract: The prevalence of chronic kidney disease (CKD) is rapidly increasing over the last few decades, owing to the global increase in diabetes, and cardiovascular diseases. Dialysis greatly compromises the life quality of patients, while demand… read more here.
Keywords: organoid models; kidney diseases; kidney; kidney disease ... See more keywords
Organoid Models for Precision Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.770465
Abstract: Cancer immunotherapy is exploited for the treatment of disease by modulating the immune system. Since the conventional in vivo animal and 2D in vitro models insufficiently recapitulate the complex tumor immune microenvironment (TIME) of the… read more here.
Keywords: time; organoid models; immunotherapy; tumor ... See more keywords
Organoids: Construction and Application in Gastric Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13050875
Abstract: Gastric organoids are biological models constructed in vitro using stem cell culture and 3D cell culture techniques, which are the latest research hotspots. The proliferation of stem cells in vitro is the key to gastric… read more here.
Keywords: culture; construction application; organoid models; gastric cancer ... See more keywords
MicroRNA-223 Suppresses Human Hepatic Stellate Cell Activation Partly via Regulating the Actin Cytoskeleton and Alleviates Fibrosis in Organoid Models of Liver Injury
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169380
Abstract: MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate target mRNA expression, and altered expression of miRNAs is associated with liver pathological conditions. Recent studies in animal models have shown neutrophil/myeloid-specific microRNA-223 (miR-223) as a… read more here.
Keywords: hscs; organoid models; microrna 223; mir 223 ... See more keywords
Are the Organoid Models an Invaluable Contribution to ZIKA Virus Research?
Sign Up to like & getrecommendations! Published in 2021 at "Pathogens"
DOI: 10.3390/pathogens10101233
Abstract: In order to prevent new pathogen outbreaks and avoid possible new global health threats, it is important to study the mechanisms of microbial pathogenesis, screen new antiviral agents and test new vaccines using the best… read more here.
Keywords: research; invaluable contribution; models invaluable; organoid models ... See more keywords