Kidney organoid systems for studies of immune-mediated kidney diseases: challenges and opportunities
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DOI: 10.1007/s00441-021-03499-4
Abstract: Acute and chronic kidney diseases are major contributors to morbidity and mortality in the global population. Many nephropathies are considered to be immune-mediated with dysregulated immune responses playing an important role in the pathogenesis. At… read more here.
Keywords: kidney organoid; kidney diseases; immune mediated; mediated kidney ... See more keywords
Human organoid systems in modeling reproductive tissue development, function, and disease.
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DOI: 10.1093/humrep/dead085
Abstract: Research focused on human reproductive biology has primarily relied upon clinical samples affording mainly descriptive studies with limited implementation of functional or mechanistic understanding. More importantly, restricted access to human embryonic material has necessitated the… read more here.
Keywords: systems modeling; function; development; modeling reproductive ... See more keywords
Advances in neural organoid systems and their application in neurotoxicity testing of environmental chemicals
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DOI: 10.1186/s41021-021-00214-1
Abstract: Due to the complex structure and function of central nervous system (CNS), human CNS in vitro modeling is still a great challenge. Neurotoxicity testing of environmental chemicals mainly depends on the traditional animal models, which… read more here.
Keywords: testing environmental; environmental chemicals; neural organoid; organoid systems ... See more keywords