Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis
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DOI: 10.1136/gutjnl-2017-315920
Abstract: Objective Serrated colorectal cancer (CRC) accounts for approximately 25% of cases and includes tumours that are among the most treatment resistant and with worst outcomes. This CRC subtype is associated with activating mutations in the… read more here.
Keywords: serrated crc; genetic editing; organoids provides; carcinogenesis ... See more keywords