Collagen hydrogels loaded with fibroblast growth factor-2 as a bridge to repair brain vessels in organotypic brain slices
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Brain Research"
DOI: 10.1007/s00221-020-05907-7
Abstract: Vessel damage is a general pathological process in many neurodegenerative disorders, as well as spinal cord injury, stroke, or trauma. Biomaterials can present novel tools to repair and regenerate damaged vessels. The aim of the… read more here.
Keywords: collagen; organotypic brain; growth factor; brain ... See more keywords
Nerve growth factor released from collagen scaffolds protects axotomized cholinergic neurons of the basal nucleus of Meynert in organotypic brain slices
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2017.12.003
Abstract: BACKGROUND Alzheimeŕs disease is accompanied by cell death of cholinergic neurons, resulting in cognitive impairment and memory loss. Nerve growth factor (NGF) is the most potent protein to support survival of cholinergic neurons. NEW METHOD… read more here.
Keywords: organotypic brain; cholinergic neurons; collagen scaffolds; brain slices ... See more keywords
Abstract 4611: Leveraging organotypic brain slice models to enhance adoptive cellular therapies
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4611
Abstract: Glioblastoma (GBM) is an incredibly aggressive and prevalent primary CNS tumor with dismal survival outcomes. GBM’s intra-tumor heterogeneity and lack of anti-tumor immune cell infiltration have proved to be formidable challenges to the development of… read more here.
Keywords: brain slice; leveraging organotypic; slice models; tumor ... See more keywords
Melatonin Supports the Survival of Cholinergic Neurons in Organotypic Brain Slices of the Basal Nucleus of Meynert
Sign Up to like & getrecommendations! Published in 2023 at "Pharmacology"
DOI: 10.1159/000527887
Abstract: The nucleus basalis of Meynert (nBM) is the major source of cholinergic neurons in the basal forebrain, which require nerve growth factor (NGF) for their survival. Melatonin, a pleiotropic hormone, has been shown to exert… read more here.
Keywords: cholinergic neurons; brain slices; melatonin; survival cholinergic ... See more keywords
Organotypic Brain Slices of ADULT Transgenic Mice: A Tool to Study Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Current Alzheimer research"
DOI: 10.2174/1567205016666181212153138
Abstract: Transgenic mice have been extensively used to study the Alzheimer pathology. In order to reduce, refine and replace (3Rs) the number of animals, ex vivo cultures are used and optimized. Organotypic brain slices are the… read more here.
Keywords: brain slices; transgenic mice; organotypic brain; brain ... See more keywords
Melatonin Activates Anti-Inflammatory Features in Microglia in a Multicellular Context: Evidence from Organotypic Brain Slices and HMC3 Cells
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13020373
Abstract: Melatonin (MEL) is a neurohormone endowed with neuroprotective activity, exerted both directly on neuronal cells and indirectly through modulation of responsive glial cells. In particular, MEL’s effects on microglia are receptor-mediated and in part dependent… read more here.
Keywords: multicellular context; mel; anti inflammatory; context ... See more keywords
Studies on Biological and Molecular Effects of Small-Molecule Kinase Inhibitors on Human Glioblastoma Cells and Organotypic Brain Slices
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12081258
Abstract: Glioblastoma is the most common and aggressive primary brain tumor. Multiple genetic and epigenetic alterations in several major signaling pathways—including the phosphoinositide 3-kinases (PI3K)/AKT/mTOR and the Raf/MEK/ERK pathway—could be found. We therefore aimed to investigate… read more here.
Keywords: effects small; brain slices; glioblastoma; brain ... See more keywords