Activation of EP2 receptor suppresses poly(I: C) and LPS‐mediated inflammation in primary microglia and organotypic hippocampal slice cultures: Contributing role for MAPKs
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23276
Abstract: Brain inflammation is a critical factor involved in neurodegeneration. Recently, the prostaglandin E2 (PGE2) downstream members were suggested to modulate neuroinflammatory responses accompanying neurodegenerative diseases. In this study, we investigated the protective effects of prostaglandin… read more here.
Keywords: ep2 receptor; primary microglia; organotypic hippocampal; hippocampal slice ... See more keywords
Preparation and Culture of Organotypic Hippocampal Slices for the Analysis of Brain Metastasis and Primary Brain Tumor Growth.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1350-4_5
Abstract: Brain metastasis is a major challenge for therapy and defines the end stage of tumor progression with a very limited patients' prognosis. Experimental setups that faithfully mimic these processes are necessary to understand the mechanism… read more here.
Keywords: organotypic hippocampal; brain metastasis; culture; brain ... See more keywords
Neuroprotective effects of N-acetylcysteine amide against oxidative injury in an aging model of organotypic hippocampal slice cultures
Sign Up to like & getrecommendations! Published in 2022 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001767
Abstract: Objectives Oxidative stress produces neurotoxicity and has been associated with disorders of the nervous system. We observed the neuroprotective effects of N-acetylcysteine amide (NACA) against kainic acid (KA)-induced oxidative stress in aging organotypic hippocampal slice… read more here.
Keywords: effects acetylcysteine; neuroprotective effects; acetylcysteine amide; treatment ... See more keywords
Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2019.00168
Abstract: Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system… read more here.
Keywords: month old; organotypic hippocampal; kinin receptor; receptor ... See more keywords
Organotypic hippocampal slices, an emerging tool to model synucleinopathies
Sign Up to like & getrecommendations! Published in 2021 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.297065
Abstract: The pathological hallmark of PD is the presence of neuronal cytoplasmic inclusions called Lewy bodies (LB) or Lewy neurites, which consist of the abundant presynaptic protein alphasynuclein (α-syn) in an aggregated form. Apart from being… read more here.
Keywords: model synucleinopathies; slices emerging; hippocampal slices; organotypic hippocampal ... See more keywords