Organs-on-a-chip: Current applications and consideration points for in vitro ADME-Tox studies.
Sign Up to like & getrecommendations! Published in 2018 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2018.01.003
Abstract: Assay systems using in vitro cultured cells are increasingly applied for evaluation of the efficacy, safety, and toxicity of drug candidates. In vitro cell-based assays have two main applications in the drug discovery process: searching for a… read more here.
Keywords: system; organs chip; drug; vitro adme ... See more keywords
Organs-on-chip: The way forward
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.06.015
Abstract: Organ-on-chip (OoC) technology is thriving thanks to stem cells availability and international OoC programs. Concerted standardization, qualification, and independent testing of devices are needed to coherently develop OoC technology further and fulfill its potential in… read more here.
Keywords: medicine; organs chip; way forward; chip ... See more keywords
Organs on chip approach: a tool to evaluate cancer -immune cells interactions
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13070-3
Abstract: In this paper we discuss the applicability of numerical descriptors and statistical physics concepts to characterize complex biological systems observed at microscopic level through organ on chip approach. To this end, we employ data collected… read more here.
Keywords: cancer; organs chip; chip approach; wild type ... See more keywords
Investigation and comparison of resin materials in transparent DLP-printing for application in cell culture and organs-on-a-chip.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d1bm01794b
Abstract: Organs-on-a-Chip (OOCs) have recently led to major discoveries and a better understanding of 3D cell organization, cell-cell interactions and tissue response to drugs and biological cues. However, their complexity and variability are still limited by… read more here.
Keywords: dlp printing; cell; printing; organs chip ... See more keywords
Incorporating mechanical strain in organs-on-a-chip: Lung and skin
Sign Up to like & getrecommendations! Published in 2018 at "Biomicrofluidics"
DOI: 10.1063/1.5024895
Abstract: In the last decade, the advent of microfabrication and microfluidics and an increased interest in cellular mechanobiology have triggered the development of novel microfluidic-based platforms. They aim to incorporate the mechanical strain environment that acts… read more here.
Keywords: mechanical strain; incorporating mechanical; organs chip; strain organs ... See more keywords
In Vitro Immune Organs-on-Chip for Drug Development: A Review
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics10040278
Abstract: The current drug development practice lacks reliable and sensitive techniques to evaluate the immunotoxicity of drug candidates, i.e., their effect on the human immune system. This, in part, has resulted in a high attrition rate… read more here.
Keywords: drug development; organs chip; drug; immune organs ... See more keywords