Human Organoids and Organs‐on‐Chips for Addressing COVID‐19 Challenges
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105187
Abstract: Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), poses an imminent threat to our lives. Although animal models and monolayer cell cultures are utilized for pathogenesis studies and the development… read more here.
Keywords: organoids organs; human organoids; organs chips; covid ... See more keywords
Organs-on-chips: research and commercial perspectives.
Sign Up to like & getrecommendations! Published in 2017 at "Drug discovery today"
DOI: 10.1016/j.drudis.2016.11.009
Abstract: Traditional preclinical drug testing methods utilize animal models to predict pharmacology and toxicology profiles. However, the data obtained from such methods cannot be directly extrapolated to humans and often do not provide a safe starting… read more here.
Keywords: organs chips; drug; commercial perspectives; chips research ... See more keywords
Organs-on-chips for vascular function
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology Letters"
DOI: 10.1016/j.toxlet.2017.07.069
Abstract: Organs-on-chips are plastic microdevices the size of a USB-stick with microchannels and small chambers that are filled with liquid. The devices contain multiple human cell types which are cultured in a technologically controlled microenvironment that… read more here.
Keywords: organs chips; chips vascular; toxicology; vascular function ... See more keywords
Toward a modular, integrated, miniaturized, and portable microfluidic flow control architecture for organs-on-chips applications.
Sign Up to like & getrecommendations! Published in 2022 at "Biomicrofluidics"
DOI: 10.1063/5.0074156
Abstract: Microfluidic organs-on-chips (OoCs) technology has emerged as the trend for in vitro functional modeling of organs in recent years. Simplifying the complexities of the human organs under controlled perfusion of required fluids paves the way… read more here.
Keywords: flow control; control; organs chips; architecture ... See more keywords
Organs-on-chips take baby steps
Sign Up to like & getrecommendations! Published in 2019 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aax1713
Abstract: Two organ-on-chip devices enable investigation of cellular interactions in human fetal membranes in vitro. Two organ-on-chip devices enable investigation of cellular interactions in human fetal membranes in vitro. read more here.
Keywords: medicine; organs chips; chips take; take baby ... See more keywords
Organs-on-Chips Platforms Are Everywhere: A Zoom on Biomedical Investigation
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineering"
DOI: 10.3390/bioengineering9110646
Abstract: Over the decades, conventional in vitro culture systems and animal models have been used to study physiology, nutrient or drug metabolisms including mechanical and physiopathological aspects. However, there is an urgent need for Integrated Testing… read more here.
Keywords: zoom biomedical; everywhere zoom; organs chips; physiology ... See more keywords
The Synergy between Deep Learning and Organs-on-Chips for High-Throughput Drug Screening: A Review
Sign Up to like & getrecommendations! Published in 2023 at "Biosensors"
DOI: 10.3390/bios13030389
Abstract: Organs-on-chips (OoCs) are miniature microfluidic systems that have arguably become a class of advanced in vitro models. Deep learning, as an emerging topic in machine learning, has the ability to extract a hidden statistical relationship… read more here.
Keywords: organs chips; drug screening; deep learning; screening review ... See more keywords
Multi-Organs-on-Chips for Testing Small-Molecule Drugs: Challenges and Perspectives
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13101657
Abstract: Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in… read more here.
Keywords: multi organs; molecule drugs; organs chips; small molecule ... See more keywords