The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry
Sign Up to like & getrecommendations! Published in 2021 at "Diabetologia"
DOI: 10.1007/s00125-021-05552-x
Abstract: The minor A allele of rs373863828 (CREBRF p.Arg457Gln) is associated with increased BMI, but reduced risk of type 2 and gestational diabetes in Polynesian (Pacific peoples and Aotearoa New Zealand Māori) populations. This study investigates… read more here.
Keywords: insulin; rs373863828; insulin release; ancestry ... See more keywords
A014 Governance of Research to Achieve Equity in Cardiovascular Health Outcomes: MENZACS
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DOI: 10.1016/j.hlc.2020.05.019
Abstract: Background: A marked equity gap is acknowledged in almost all health outcomes for Māori and Pacific people in Aotearoa In CV health, the gap is across all major markers of CVD risk and morbidity and… read more here.
Keywords: equity; research; health outcomes; governance ... See more keywords
Widespread prevalence of a CREBRF variant amongst Māori and Pacific children is associated with weight and height in early childhood
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Obesity"
DOI: 10.1038/ijo.2017.230
Abstract: Objective:Investigating a large and ethnically diverse cohort from the Pacific region, we aimed to replicate and extend the recently reported findings that a CREBRF genetic variant is strongly associated with body mass index in Samoans.Methods:A… read more here.
Keywords: rs373863828; variant; ori pacific; crebrf variant ... See more keywords
1245Culturally-appropriate research supporting a co-designed childhood obesity prevention program tailored for Māori & Pacific Islanders
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Epidemiology"
DOI: 10.1093/ije/dyab168.262
Abstract: Children of Māori & Pacific Islander descent living in Australia experience higher rates of obesity, increasing their risk of developing life diminishing chronic diseases. However, community-based, childhood obesity prevention programs, tailored to the Māori &… read more here.
Keywords: childhood; ori pacific; obesity prevention; program ... See more keywords
Mitochondrial genetic variation and gout in Māori and Pacific people living in Aotearoa New Zealand
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DOI: 10.1136/annrheumdis-2017-212416
Abstract: Objective Mitochondria have an important role in the induction of the NLRP3 inflammasome response central in gout. The objective was to test whether mitochondrial genetic variation and copy number in New Zealand Māori and Pacific… read more here.
Keywords: aotearoa new; copy number; new zealand; ori pacific ... See more keywords
What are the gaps in cardiovascular risk assessment and management in primary care for Māori and Pacific people in Aotearoa New Zealand? Protocol for a systematic review
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DOI: 10.1136/bmjopen-2021-060145
Abstract: Introduction In New Zealand, significant inequities exist between Māori and Pacific peoples compared with non-Māori, non-Pacific peoples in cardiovascular disease (CVD) risk factors, hospitalisations and management rates. This review will quantify and qualify already-reported gaps… read more here.
Keywords: ori pacific; pacific peoples; risk; new zealand ... See more keywords
Genetic testing for misclassified monogenic diabetes in Māori and Pacific peoples in Aōtearoa New Zealand with early-onset type 2 diabetes
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DOI: 10.3389/fendo.2023.1174699
Abstract: Aims Monogenic diabetes accounts for 1-2% of diabetes cases yet is often misdiagnosed as type 2 diabetes. The aim of this study was to examine in Māori and Pacific adults clinically diagnosed with type 2… read more here.
Keywords: ori pacific; pacific peoples; type diabetes; monogenic diabetes ... See more keywords
Allelic diversity of the pharmacogene CYP2D6 in New Zealand Māori and Pacific peoples
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DOI: 10.3389/fgene.2022.1016416
Abstract: The enzyme cytochrome P450 2D6 (CYP2D6) metabolises approximately 25% of commonly prescribed drugs, including analgesics, anti-hypertensives, and anti-depressants, among many others. Genetic variation in drug metabolising genes can alter how an individual responds to prescribed… read more here.
Keywords: ori pacific; diversity pharmacogene; new zealand; pharmacogene cyp2d6 ... See more keywords