Oridonin‐induced mitochondria‐dependent apoptosis in esophageal cancer cells by inhibiting PI3K/AKT/mTOR and Ras/Raf pathways
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27654
Abstract: Oridonin, an active diterpenoid isolated from Rabdosia rubescens, has been reported for its antitumor activity on several cancers. However, its effect on human esophageal cancer remains unclear. In this study, we demonstrated that oridonin could… read more here.
Keywords: esophageal cancer; oridonin; pi3k akt; cancer cells ... See more keywords
PLC1 and H2O2 Mediated the Allelopathic Effect of Oridonin on Root Growth in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Plant Growth Regulation"
DOI: 10.1007/s00344-021-10370-x
Abstract: Oridonin is a diterpenoid isolated from medicinal herb Rabdosia rubescens (Hemsl.) Hara (Lamiaceae), which has an allelopathic effect on plants. Phospholipase C (PLC1) and hydrogen peroxide (H2O2) are involved in many biotic or abiotic stress… read more here.
Keywords: growth; root growth; oridonin; plc1 ... See more keywords
Oridonin prevents epithelial-mesenchymal transition and TGF-β1-induced epithelial-mesenchymal transition by inhibiting TGF-β1/Smad2/3 in osteosarcoma.
Sign Up to like & getrecommendations! Published in 2018 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2018.09.013
Abstract: Osteosarcoma is the most common primary bone tumor with highly invasive characteristic and low long-term survival. Recently, epithelial-mesenchymal transition (EMT) is reported as a key event in cancer invasion and metastasis. Oridonin, a bioactive diterpenoid,… read more here.
Keywords: oridonin; mesenchymal transition; oridonin inhibited; epithelial mesenchymal ... See more keywords
Preliminary safety assessment of oridonin in zebrafish
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2019.1662457
Abstract: Abstract Context: Oridonin, isolated from the leaves of Isodon rubescens (Hemsl.) H.Hara (Lamiaceae), has good antitumor activity. However, its safety in vivo is still unclear. Objective: To investigate the preliminary safety of oridonin in zebrafish.… read more here.
Keywords: safety assessment; oridonin; hpf; oridonin zebrafish ... See more keywords
Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2020.1711783
Abstract: Abstract Context Oridonin exhibits various pharmacological and physiological activities, including antioxidant, antibacterial, anti-inflammatory, pro-apoptotic, anticancer and neurological effects. However, its role in rheumatoid arthritis (RA) is yet to be revealed. Objective We evaluated the effects… read more here.
Keywords: oridonin; fibroblast like; rheumatoid arthritis; like synoviocytes ... See more keywords
Oridonin inhibits the migration and epithelial‐to‐mesenchymal transition of small cell lung cancer cells by suppressing FAK‐ERK1/2 signalling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15106
Abstract: Small cell lung cancer (SCLC) is a severe malignant with high morbidity; however, few effective and secure therapeutic strategy is used in current clinical practice. Oridonin is a small molecule from the traditional Chinese herb… read more here.
Keywords: oridonin; cell lung; lung cancer; fak erk1 ... See more keywords
Oridonin Attenuates Burkholderia cenocepacia Virulence by Suppressing Quorum-Sensing Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01787-22
Abstract: Burkholderia cenocepacia is an important human opportunistic pathogen that can cause life-threatening infections in susceptible individuals. It employs quorum-sensing (QS) systems to regulate biological functions and virulence. ABSTRACT Burkholderia cenocepacia is a human opportunistic pathogen… read more here.
Keywords: burkholderia cenocepacia; bdsf; virulence; quorum sensing ... See more keywords
Oridonin Relieves Angiotensin II-Induced Cardiac Remodeling via Inhibiting GSDMD-Mediated Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular Therapeutics"
DOI: 10.1155/2022/3167959
Abstract: Myocardial remodeling is one of the main lesions in the late stage of chronic heart failure and seriously affects the prognosis of patients. Continuous activation of the renin-angiotensin-aldosterone system (RAAS) contributes to the development of… read more here.
Keywords: inflammation; inhibiting gsdmd; myocardial remodeling; cardiac remodeling ... See more keywords
Oridonin Protects against Myocardial Ischemia–Reperfusion Injury by Inhibiting GSDMD-Mediated Pyroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13112133
Abstract: Pyroptosis serves a crucial function in various types of ischemia and reperfusion injuries. Oridonin, a tetracycline diterpene derived from Rabdosia rubescens, can significantly inhibit the aggregation of NLRP3-mediated inflammasome. This experiment is aimed at investigating… read more here.
Keywords: pyroptosis; myocardial ischemia; oridonin; injury ... See more keywords
Oridonin inhibits growth and induces apoptosis of human neurocytoma cells via the Wnt/β-catenin pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology letters"
DOI: 10.3892/ol.2018.8977
Abstract: Central neurocytoma (CN) is a rare periventricular tumor of the central nervous system in young adults. Typically, patients with CN exhibit a favorable prognosis, but in certain cases the clinical course is more aggressive. Therefore,… read more here.
Keywords: oridonin; apoptosis; catenin; pathway ... See more keywords