IMCR coupled one-pot process: Efficient tools to Diversity-Oriented Synthesis of structural peptidomimetics containing heterocyclic bioisosteres and DFT conformational studies.
Sign Up to like & getrecommendations! Published in 2024 at "ChemPlusChem"
DOI: 10.1002/cplu.202300633
Abstract: Multicomponent diversity-oriented synthesis (DOS) of conformationally anchored structural peptidomimetics like 2,5-diketopiperazines (2,5-DKP) containing heterocyclic bioisosteres of the amide bond, such as 1,2,3-triazoles and 1,5-disubstituted tetrazoles (1,5-DS-T) is described. Structural peptidomimetics are synthesized from similar available starting… read more here.
Keywords: diversity oriented; structural peptidomimetics; heterocyclic bioisosteres; oriented synthesis ... See more keywords
Diversity‐Oriented Synthesis of Carbohydrate Scaffolds through the Prins Cyclization of Differently Protected d‐Mannitol‐Derived Homoallylic Alcohols
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201701172
Abstract: A diversity oriented synthesis of a variety of carbohydrate scaffolds such as sugar fused isochroman derivatives, bicyclic vinyl halide derivatives, fluorine substituted tetrahydropyrans, and a furan derivative is reported. This has been achieved by using… read more here.
Keywords: diversity oriented; carbohydrate scaffolds; derived homoallylic; homoallylic alcohols ... See more keywords
Target-Oriented Synthesis of Borate Derivatives Featuring Isolated [B3O3] Six-Membered Rings as Structural Features.
Sign Up to like & getrecommendations! Published in 2023 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.3c01112
Abstract: Borates provide an excellent platform for investigating the optical nonlinearity and linearity of crystals as photoelectric functional materials. In our work, borate derivatives with isolated [B3O3] six-membered rings as structural features are the preferred system… read more here.
Keywords: borate derivatives; chemistry; target oriented; oriented synthesis ... See more keywords
Diversity-Oriented Synthesis of Fluoromethylated Arenes via Palladium-Catalyzed C-H Fluoromethylation of Aryl Iodides.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04367
Abstract: Herein we report the first versatile and expeditious method for the site-selective C-H fluoromethylation of aryl iodides via Pd/norbornene cooperative catalysis, which could work as a robust toolbox for the diversity-oriented synthesis (DOS) of fluoromethylated… read more here.
Keywords: oriented synthesis; aryl iodides; fluoromethylated arenes; diversity oriented ... See more keywords
Diversity-Oriented Synthesis of ERα Modulators via Mitsunobu Macrocyclization.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01239
Abstract: The diversity of cyclic peptides was expanded by elaborating Mitsunobu macrocyclization, tethering various hydroxy acid building blocks with different Nε-amine substituents. This new strategy was then applied in synthesizing peptidomimetic estrogen receptor modulator (PERM) analogs… read more here.
Keywords: oriented synthesis; diversity; mitsunobu macrocyclization; diversity oriented ... See more keywords
Diversity-Oriented Synthesis of Glycosylphosphatidylinositol Probes Based on an Orthogonally Protected Pentasaccharide.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00448
Abstract: Two glycosylphosphatidylinositol (GPI) derivatives having an alkynyl group at different positions were derived from the same orthogonally protected pentasaccharide that in turn was assembled by a convergent [3+2] glycosylation strategy. The resultant alkynylated GPIs are… read more here.
Keywords: synthesis glycosylphosphatidylinositol; orthogonally protected; oriented synthesis; diversity oriented ... See more keywords
Target-Oriented Synthesis of Triphenylphosphine Functionalized Carbon Dots with Negative Charge for ROS Scavenging and Mitochondrial Targeting.
Sign Up to like & getrecommendations! Published in 2024 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.4c01382
Abstract: Triphenylphosphine functionalized carbon dots (TPP-CDs) showcase robust mitochondria targeting capacity owing to their positive electrical properties. However, TPP-CDs typically involve complicated synthesis steps and time-consuming postmodification procedures. Especially, the one-step target-oriented synthesis of TPP-CDs and… read more here.
Keywords: carbon dots; tpp; target oriented; synthesis ... See more keywords
Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.
Sign Up to like & getrecommendations! Published in 2017 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.6b00206
Abstract: In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options currently exist, many of… read more here.
Keywords: oriented synthesis; clostridium difficile; diversity oriented; identification highly ... See more keywords
Step-Economical Photoassisted Diversity-Oriented Synthesis: Sustaining Cascade Photoreactions in Oxalyl Anilides to Access Complex Polyheterocyclic Molecular Architectures.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b07598
Abstract: Atom- and step-economy in photoassisted diversity-oriented synthesis (DOS) is achieved with a versatile oxalyl linker offering rapid access to complex alkaloid mimics in very few experimentally simple steps: (i) it allows for fast tethering of… read more here.
Keywords: photoassisted diversity; diversity oriented; molecular architectures; access complex ... See more keywords
Diversity-oriented synthesis of imidazo[2,1-a]isoquinolines.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc05390a
Abstract: Herein, we report an efficient and practical strategy for the synthesis of five types of imidazo[2,1-a]isoquinolines via Cp*RhIII-catalyzed [4+2] annulation of 2-arylimidazoles and α-diazoketoesters, whose structural and substituted diversity at 5- or 6-position can be… read more here.
Keywords: diversity oriented; imidazo isoquinolines; oriented synthesis; synthesis imidazo ... See more keywords
A diversity-oriented synthesis of polyheterocycles via the cyclocondensation of azomethine imine
Sign Up to like & getrecommendations! Published in 2019 at "New Journal of Chemistry"
DOI: 10.1039/c9nj02874a
Abstract: Pd-Catalyzed sequential reactions to afford skeletally diverse molecules are described. read more here.
Keywords: oriented synthesis; cyclocondensation azomethine; synthesis polyheterocycles; polyheterocycles via ... See more keywords