Differential analysis of Orientia tsutsugamushi genomes for therapeutic target identification and possible intervention through natural product inhibitor screening
Sign Up to like & getrecommendations! Published in 2022 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2021.105165
Abstract: Orientia tsutsugamushi (Ott) is a causative agent of scrub typhus, and one of the emerging pathogens that could affect a large human population. It is one of the misdiagnosed and under-reported, febrile illnesses that infects… read more here.
Keywords: orientia tsutsugamushi; target; product; natural product ... See more keywords
Pan-proteome profiling of emerging and re-emerging zoonotic pathogen Orientia tsutsugamushi for getting insight in to microbial pathogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2021.105103
Abstract: With the occurrence and evolution of antibiotic and multidrug resistance in bacteria most of the existing remedies are becoming ineffective. The pan-proteome exploration of the bacterial pathogens helps to identify the wide spectrum therapeutic targets… read more here.
Keywords: pan proteome; orientia tsutsugamushi; pathogen orientia; therapeutic targets ... See more keywords
Metabolic characterization of serum from mice challenged with Orientia tsutsugamushi–infected mites
Sign Up to like & getrecommendations! Published in 2018 at "New Microbes and New Infections"
DOI: 10.1016/j.nmni.2018.01.005
Abstract: Scrub typhus is an acute zoonosis caused by the obligate intracellular Gram-negative bacterium Orientia tsutsugamushi. To better understand the host response elicited by natural infection by chigger feeding, ICR mice were infected by Leptotrombidium chiangraiensis… read more here.
Keywords: orientia tsutsugamushi; mice infected; tsutsugamushi; serum ... See more keywords
The incidence of Orientia tsutsugamushi infection in rural South India
Sign Up to like & getrecommendations! Published in 2022 at "Epidemiology and Infection"
DOI: 10.1017/s0950268822001170
Abstract: Abstract Scrub typhus is a common bacterial infection in Asia caused by Orientia tsutsugamushi. This serological cohort study estimated the incidence of infection in a rural population in South India. Participants were enrolled through systematic… read more here.
Keywords: south india; incidence; orientia tsutsugamushi; incidence orientia ... See more keywords
Detection of Orientia tsutsugamushi in Novel Trombiculid Mite Species in Northern Tamil Nadu, India: Use of Targeting the Multicopy traD Gene.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medical entomology"
DOI: 10.1093/jme/tjab180
Abstract: Detection of Orientia tsutsugamushi DNA in a trombiculid mite chigger species suggests that it might be a potential vector of scrub typhus in an endemic area. Over a period of 20 mo, 85 rats were… read more here.
Keywords: detection orientia; orientia tsutsugamushi; trad; gene ... See more keywords
Genetic diversity of Orientia tsutsugamushi strains circulating in Northeast India
Sign Up to like & getrecommendations! Published in 2018 at "Transactions of The Royal Society of Tropical Medicine and Hygiene"
DOI: 10.1093/trstmh/try019
Abstract: Background Scrub typhus, caused by the intracellular bacteria Orientia tsutsugamushi is widely distributed in Southeast Asian countries with antigenically divergent strains reported across the Asia-Pacific belt. The present study was conducted to characterize the circulating… read more here.
Keywords: genetic diversity; gene; orientia tsutsugamushi;
Occurrence rates of wild rodent hosts and chigger mites and the infection rate of Orientia tsutsugamushi in the central region of South Korea from 2015 to 2018
Sign Up to like & getrecommendations! Published in 2019 at "Entomological Research"
DOI: 10.1111/1748-5967.12387
Abstract: Outbreaks of vector‐borne diseases are dramatically increasing because of climate change, consequently increasing the importance of surveillance of endemic disease vectors. In this study, we surveyed chigger mites, vectors for Orientia tsutsugamushi—the bacteria that causes… read more here.
Keywords: chigger mites; orientia tsutsugamushi; rodent hosts; south korea ... See more keywords
Orientia tsutsugamushi Is Highly Susceptible to the RNA Polymerase Switch Region Inhibitor Corallopyronin A In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01732-17
Abstract: ABSTRACT Scrub typhus is a potentially lethal infection caused by the obligate intracellular bacterium Orientia tsutsugamushi. Reports on the emergence of doxycycline-resistant strains highlight the urgent need to develop novel antiinfectives against scrub typhus. Corallopyronin… read more here.
Keywords: orientia tsutsugamushi; vivo; tsutsugamushi; rna polymerase ... See more keywords
Reply to Tantibhedhyangkul et al., ‘Suspected Mycoplasma Contamination in the Study “Toll-Like Receptor 2 Recognizes Orientia tsutsugamushi and Increases Susceptibility to Murine Experimental Scrub Typhus”’
Sign Up to like & getrecommendations! Published in 2017 at "Infection and Immunity"
DOI: 10.1128/iai.00326-17
Abstract: Tantibhedhyangkul et al. speculate that the data presented in our recent study ([1][1]) may have been influenced by Mycoplasma sp. contaminating the Karp strain of Orientia tsutsugamushi. They raise attention to a relevant point that… read more here.
Keywords: toll like; orientia tsutsugamushi; tantibhedhyangkul; study ... See more keywords
Orientia tsutsugamushi OtDUB Is Expressed and Interacts with Adaptor Protein Complexes during Infection
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Immunity"
DOI: 10.1128/iai.00469-22
Abstract: Orientia tsutsugamushi is an etiologic agent of scrub typhus, a globally emerging rickettsiosis that can be fatal. The bacterium’s obligate intracellular lifestyle requires its interaction with host eukaryotic cellular pathways. ABSTRACT Orientia tsutsugamushi is an… read more here.
Keywords: protein complexes; adaptor protein; orientia tsutsugamushi; infection ... See more keywords
Genotypic characterization of Orientia tsutsugamushi from patients in two geographical locations in Sri Lanka
Sign Up to like & getrecommendations! Published in 2017 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-016-2165-z
Abstract: BackgroundTo date more than 20 antigenically distinct strains of Orientia tsutsugamushi (OT) reported within the tsutsugamushi triangle that cause an undifferentiated acute febrile illness in humans. Genotypic characterization of OT in different geographic regions or… read more here.
Keywords: close homology; orientia tsutsugamushi; sri lanka; genotypic characterization ... See more keywords