A novel mouse model of diffuse midline glioma initiated in neonatal oligodendrocyte progenitor cells highlights cell‐of‐origin dependent effects of H3K27M
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DOI: 10.1002/glia.24189
Abstract: Diffuse midline glioma (DMG) is a type of lethal brain tumor that develops mainly in children. The majority of DMG harbor the K27M mutation in histone H3. Oligodendrocyte progenitor cells (OPCs) in the brainstem are… read more here.
Keywords: diffuse midline; mouse; origin dependent; midline glioma ... See more keywords
Cell origin–dependent cooperativity of mutant Dnmt3a and Npm1 in clonal hematopoiesis and myeloid malignancy
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DOI: 10.1182/bloodadvances.2022006968
Abstract: Key Points Selective advantage induced by clonal hematopoiesis-associated mutation in Dnmt3a is specific to the HSC compartment. Npm1 mutation alters chromatin accessibility in a cell-context and Dnmt3a mutation-dependent manner. read more here.
Keywords: dependent cooperativity; origin dependent; dnmt3a; cell origin ... See more keywords