Mechanism of parent-of-origin effects revealed by multi-omic data in euro-chinese hybrid pigs
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DOI: 10.1038/s41467-025-62243-6
Abstract: Parent-of-origin effects refer to the phenomenon whereby the gene expression and corresponding phenotype are influenced by paternal or maternal origin, and uncovering the underlying regulatory mechanisms remains a challenging task. To address this, we designed… read more here.
Keywords: origin; mechanism parent; parent origin; origin effects ... See more keywords
Parent-of-origin effects on complex traits in up to 236,781 individuals
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DOI: 10.1038/s41586-025-09357-5
Abstract: Parent-of-origin effects (POEs) occur when the effect of a genetic variant depends on its parental origin1. Traditionally linked to genomic imprinting, POEs are believed to occur due to parental conflict over resource allocation to offspring,… read more here.
Keywords: complex traits; parent origin; origin effects; effects complex ... See more keywords
Nerves in the Tumor Microenvironment: Origin and Effects
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.601738
Abstract: Studies have reported the vital role of nerves in tumorigenesis and cancer progression. Nerves infiltrate the tumor microenvironment thereby enhancing cancer growth and metastasis. Perineural invasion, a process by which cancer cells invade the surrounding… read more here.
Keywords: origin effects; microenvironment origin; nerves tumor; cancer cells ... See more keywords