TopBP1 utilises a bipartite GINS binding mode to support genome replication
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-45946-0
Abstract: Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for replication origin firing, and as such for faithful genetic inheritance. Our biochemical and structural studies demonstrate that the helicase activator GINS… read more here.
Keywords: replication; origin firing; topbp1 utilises; topbp1 gins ... See more keywords
The Role of MTBP as a Replication Origin Firing Factor
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11060827
Abstract: Simple Summary Copying the chromosomal DNA completely and faithfully during the process of DNA replication is key to inheriting the genetic information in an unaltered state. To achieve this, replication initiation, which generates the complex… read more here.
Keywords: replication; replication initiation; origin firing; initiation ... See more keywords