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Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28695-w
Abstract: The coordinated action of multiple replicative helicase loading factors is needed for the licensing of replication origins prior to DNA replication. Binding of the Origin Recognition Complex (ORC) to DNA initiates the ATP-dependent recruitment of…
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Keywords:
dna;
origin licensing;
cerevisiae orc;
cdc6 ... See more keywords
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Published in 2021 at "Biochemical Society transactions"
DOI: 10.1042/bst20210161
Abstract: The cell division cycle must be strictly regulated during both development and adult maintenance, and efficient and well-controlled DNA replication is a key event in the cell cycle. DNA replication origins are prepared in G1…
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Keywords:
replication;
dna replication;
origin licensing;
efficiency equity ... See more keywords
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0
Published in 2019 at "Life Science Alliance"
DOI: 10.26508/lsa.201800270
Abstract: This study suggests a novel role of the telomere-associated human CST complex in suppressing origin licensing, through interactions with MCM, while promoting the recruitment of AND-1 and DNA polymerase alpha for replisome formation. Human CTC1-STN1-TEN1…
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Keywords:
cst;
human cst;
origin licensing;
replication ... See more keywords
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0
Published in 2017 at "eLife"
DOI: 10.7554/elife.22512
Abstract: Eukaryotic replication origin licensing, activation and timing are influenced by chromatin but a mechanistic understanding is lacking. Using reconstituted nucleosomal DNA replication assays, we assessed the impact of nucleosomes on replication initiation. To generate distinct…
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Keywords:
replication initiation;
activation;
steps replication;
origin licensing ... See more keywords
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2
Published in 2022 at "eLife"
DOI: 10.7554/elife.74437
Abstract: Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-dependent kinase (Cdk1) consensus sites, SP or TP motifs. In Saccharomyces cerevisiae, Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phospho-adaptor in S phase,…
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Keywords:
cdc14;
origin licensing;
cdk1;
cdc6 ... See more keywords