Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer
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DOI: 10.1126/science.aao3130
Abstract: A signature event for organoids Human cancer genomes harbor cryptic mutational signatures that represent the cumulative effects of DNA damage and defects in DNA repair processes. Knowledge of how specific signatures originate could have a… read more here.
Keywords: origin mutational; crispr; signature; cancer ... See more keywords