Origins of halogen effects in bioorthogonal sydnone cycloadditions.
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DOI: 10.1039/c8cc02128g
Abstract: Halogen substituents increase sydnone cycloaddition reactivities substantially. Fluoro-sydnones are superior to bromo- and chloro-sydnones, and can achieve extremely high second-order rate constants with strained alkynes. Computational studies have revealed the fluorine substituent increases the reactivity… read more here.
Keywords: sydnone cycloadditions; effects bioorthogonal; origins halogen; bioorthogonal sydnone ... See more keywords