Orlistat induces apoptosis and protective autophagy in ovarian cancer cells: involvement of Akt-mTOR-mediated signaling pathway
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DOI: 10.1007/s00404-018-4841-2
Abstract: IntroductionOrlistat possesses anti-tumor capacity by inducing apoptosis in ovarian cancer cells. However, the mechanism is not clearly understood. Emerging evidence indicates the overlaps between autophagy and apoptosis. In this study, we have investigated the role… read more here.
Keywords: orlistat; apoptosis; ovarian cancer; autophagy ... See more keywords
Kaempferol inhibits the activity of pancreatic lipase and its synergistic effect with orlistat
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DOI: 10.1016/j.jff.2020.104041
Abstract: Abstract Repression of pancreatic lipase activity reduces the excessive absorption of lipids, thereby reducing the risk of being overweight and obese. In the study, the inhibition of kaempferol on pancreatic lipase was studied by various… read more here.
Keywords: orlistat; pancreatic lipase; lipase; kaempferol inhibits ... See more keywords
Orlistat-loaded solid SNEDDS for the enhanced solubility, dissolution, and in vivo performance
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DOI: 10.2147/ijn.s181175
Abstract: Background The present study aimed to develop orlistat-loaded solid self-nanoemulsifying drug delivery system preconcentrate (SSP) with the minimum use of lipid excipients for the enhanced solubility, in vitro dissolution, lipase inhibition, and in vivo performance.… read more here.
Keywords: orlistat; enhanced solubility; orlistat loaded; vivo performance ... See more keywords