Population Pharmacokinetic Analysis to Assist Dose Selection of the l-Ornithine Salt of Phenylacetic Acid
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-021-01075-1
Abstract: l-Ornithine phenylacetate is an intravenous formulation of the l-ornithine salt of phenylacetic acid under development for the treatment of hepatic encephalopathy. Very limited clinical data in patients are available, with a phase II study in… read more here.
Keywords: population pharmacokinetic; dose selection; phenylacetic acid; ornithine ... See more keywords
Improving the enzyme property of ornithine transcarbamylase from Lactobacillus brevis through site-directed mutation
Sign Up to like & getrecommendations! Published in 2020 at "Lwt - Food Science and Technology"
DOI: 10.1016/j.lwt.2020.109953
Abstract: Abstract Ornithine transcarbamylase (OTC) is an enzyme that participates in the degradation of arginine by catalyzing the formation of ornithine and carbamoyl phosphate from citrulline, which is a major precursor of ethyl carbamate (EC), a… read more here.
Keywords: directed mutation; ornithine; site directed; ornithine transcarbamylase ... See more keywords
Utilization of 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) for spectrochemical determination of l-ornithine: a multivariate optimization-assisted approach
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra03311d
Abstract: l-Ornithine was determined using NBD-Cl. A multivariate-assisted strategy was used to measure a single response as a function of five variables. read more here.
Keywords: nitrobenzo oxa; ornithine; chloro nitrobenzo; utilization chloro ... See more keywords
A possible ocular biomarker for response to hyperornithinemia in gyrate atrophy: the effect of pyridoxine, lysine, and arginine-restricted diet in a patient with advanced disease
Sign Up to like & getrecommendations! Published in 2022 at "Ophthalmic Genetics"
DOI: 10.1080/13816810.2022.2098986
Abstract: ABSTRACT Background Loss of function variants in the ornithine aminotransferase (OAT) gene cause accumulation of ornithine levels, leading to gyrate atrophy. The benefit of ornithine-lowering therapies has been documented in a mouse model and young… read more here.
Keywords: ornithine; ornithine levels; pyridoxine; gyrate atrophy ... See more keywords
A new and efficient method for producing food ingredients high in l-ornithine using unused parts of white cabbage (Brassica oleracea var. capitata).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.14384
Abstract: A surplus of unused parts of vegetables (e.g., white cabbage [cabbage] cores and outer leaves) is generated daily by factories of fresh-cut vegetables. These parts are difficult to effectively utilize and are often discarded as… read more here.
Keywords: food; method; white cabbage; ornithine ... See more keywords
Cloning and molecular characterization of Triticum aestivum ornithine amino transferase (TaOAT) encoding genes
Sign Up to like & getrecommendations! Published in 2020 at "BMC Plant Biology"
DOI: 10.1186/s12870-020-02396-2
Abstract: Ornithine aminotransferase (OAT, EC:2.6.1.13), alternatively known as ornithine delta aminotransferase (δOAT), is a pyridoxal phosphate (PLP)-dependent enzyme involved in the conversion of ornithine into glutamyl-5-semi-aldehyde (GSA) and vice versa. Up till now, there has been… read more here.
Keywords: taoat; molecular characterization; ornithine; oat ... See more keywords
Supplementation of L-Ornithine Could Increase Sleep-like Behavior in the Mouse Pups
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12121241
Abstract: Along the maternal–fetal–neonatal axis, one of the problems relating to the maternal–neonatal axis is infant sleep problems including nighttime crying. One possible solution could be to provide the newborn with sleep-promoting ingredients through breast milk… read more here.
Keywords: sleep like; increase sleep; ornithine; milk ... See more keywords
Poly-L-ornithine blocks the inhibitory effects of fibronectin on oligodendrocyte differentiation and promotes myelin repair
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.353493
Abstract: The extracellular matrix surrounding oligodendrocytes plays an important role during myelination and remyelination in the brain. In many cases, the microenvironment surrounding demyelination lesions contains inhibitory molecules, which lead to repair failure. Accordingly, blocking the… read more here.
Keywords: oligodendrocyte differentiation; inhibitory effects; poly ornithine; ornithine ... See more keywords