Ubiquitin‐independent, Proteasome‐mediated targeted degradation of KRAS in pancreatic adenocarcinoma cells using an engineered ornithine decarboxylase/antizyme system
Sign Up to like & getrecommendations! Published in 2019 at "Iubmb Life"
DOI: 10.1002/iub.1945
Abstract: The oncogene KRAS not only promotes the tumorigenesis of pancreatic cancers but also is required for the malignant progression and metastasis of these cancers. Many methods have been explored to influence the malignant biological behavior… read more here.
Keywords: degradation; ornithine decarboxylase; decarboxylase antizyme; targeted degradation ... See more keywords
Protective Effect of Lactobacillus casei on DMH-Induced Colon Carcinogenesis in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Probiotics and Antimicrobial Proteins"
DOI: 10.1007/s12602-017-9253-2
Abstract: The administration of probiotics is a promising approach to reduce the prevalence of colon cancer, a multifactorial disease, with hereditary factors, as well as environmental lifestyle-related risk factors. Biogenic polyamines, putrescine, spermidine, and spermine are… read more here.
Keywords: lactobacillus casei; colon carcinogenesis; ornithine decarboxylase; colon ... See more keywords
Ornithine decarboxylase or gamma-glutamylcysteine synthetase overexpression protects Leishmania (Vianna) guyanensis against antimony.
Sign Up to like & getrecommendations! Published in 2017 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2017.02.001
Abstract: Trypanosomatids present a unique mechanism for detoxification of peroxides that is dependent on trypanothione (bisglutathionylspermidine). Ornithine decarboxylase (ODC) and γ-glutamylcysteine synthetase (GSH1) produce molecules that are direct precursors of trypanothione. In this study, Leishmania guyanensis… read more here.
Keywords: gsh1; ornithine decarboxylase; glutamylcysteine synthetase; guyanensis ... See more keywords
Rational engineering of ornithine decarboxylase with greater selectivity for ornithine over lysine through protein network analysis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2018.07.020
Abstract: Ornithine decarboxylase (ODC) converts C5 ornithine into C4 putrescine, a monomer for polyamide synthesis. However, ODC also has minor activity towards cell metabolite C6 lysine and yields C5 cadaverine. The accumulation of cadaverine in the… read more here.
Keywords: ornithine decarboxylase; analysis; lysine; protein network ... See more keywords
Sequence Divergence in the Arginase Domain of Ornithine Decarboxylase/Arginase in Fusobacteriacea Leads to Loss of Function in Oral Associated Species.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00197
Abstract: A number of species within the Fusobacteriaceae family of Gram-negative bacteria uniquely encode for an ornithine decarboxylase/arginase (ODA) that ostensibly channels l-ornithine generated by hydrolysis of l-arginine to putrescine formation. However, two aspartate residues required… read more here.
Keywords: arginase domain; decarboxylase arginase; ornithine decarboxylase; arginase ... See more keywords
Allicin, a Potent New Ornithine Decarboxylase Inhibitor in Neuroblastoma Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.0c00613
Abstract: The natural product allicin is a reactive sulfur species (RSS) from garlic (Allium sativum L.). Neuroblastoma (NB) is an early childhood cancer arising from the developing peripheral nervous system. Ornithine decarboxylase (ODC) is a rate-limiting… read more here.
Keywords: allicin potent; inhibitor; cells allicin; ornithine decarboxylase ... See more keywords
Structure and Enzymatic Activity of an Intellectual Disability-Associated Ornithine Decarboxylase Variant, G84R
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c04702
Abstract: Ornithine decarboxylase (ODC) is a rate-limiting enzyme for the synthesis of polyamines (PAs). PAs are required for proliferation, and increased ODC activity is associated with cancer and neural over-proliferation. ODC levels and activity are therefore… read more here.
Keywords: intellectual disability; ornithine decarboxylase; g84r; activity ... See more keywords
Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214900119
Abstract: Significance Group 3 innate lymphoid cells (ILC3s) mediate immune responses in bacterial infections and autoimmunity. Intestinal ILC3s encounter metabolic signals derived from the diet and microbiota, yet the impact of these metabolites on ILC3s is… read more here.
Keywords: autoimmune colitis; ornithine decarboxylase; decarboxylase supports; supports ilc3 ... See more keywords
Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0116
Abstract: Ornithine decarboxylase (ODC) is the rate-limiting enzyme for polyamine biosynthesis and restricts M1 macrophage activation in gastrointestinal (GI) infections. However, the role of macrophage ODC in colonic epithelial-driven inflammation is unknown. Here, we investigate cell-specific… read more here.
Keywords: odc mye; ornithine decarboxylase; colitis; colitis associated ... See more keywords
Abstract 1242: Ornithine decarboxylase as a therapeutic target in endometrial cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1242
Abstract: Endometrial cancer is the 4th most common cancer and the 6th deadliest cancer in US women. The American Cancer Society estimates there will be 60,050 new endometrial cancers in 2016, an increase of more than… read more here.
Keywords: ornithine decarboxylase; endometrial cancer; cancer; endometrial cancers ... See more keywords
New insights of polyamine metabolism in testicular physiology: A role of ornithine decarboxylase antizyme inhibitor 2 (AZIN2) in the modulation of testosterone levels and sperm motility
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0209202
Abstract: The specific role of polyamines in the testis physiology is not fully understood. Antizymes (OAZs) and antizyme inhibitors (AZINs) are modulators of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis and polyamine uptake. Although… read more here.
Keywords: ornithine decarboxylase; sperm motility; physiology; role ... See more keywords