Orodispersible films: conception to quality by design.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2021.113983
Abstract: Orodispersible films (ODFs) are ultra-thin, stamp-sized, elegant, portable and patient-centric pharmaceutical dosage forms that do not need water to be ingested. They are particularly useful for paediatric and geriatric patient populations with special needs such… read more here.
Keywords: films conception; orodispersible films; quality design;
Orodispersible films based on blends of trehalose and pullulan for protein delivery
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.09.016
Abstract: &NA; During the last decades the number of therapeutic proteins increased tremendously on the pharmaceutical market. However, due to their often poor stability and limitations of the administration route, the application of therapeutic proteins is… read more here.
Keywords: protein; protein delivery; trehalose pullulan; orodispersible films ... See more keywords
Trends in the production methods of orodispersible films.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118963
Abstract: (max 200 parole) Interest in orodispersible films (ODF) is growing day-by-day, since this dosage form overcomes some therapeutic obstacles, such as impaired swallowing, and offers several benefits, such as the possibility to adapt the dosing… read more here.
Keywords: orodispersible films; production; trends production; methods orodispersible ... See more keywords
Drop-on-demand printing of personalised orodispersible films fabricated by precision micro-dispensing.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.121279
Abstract: Personalised orodispersible films (ODFs) manufactured at the point of care offer the possibility of adapting the dosing requirements for individual patients. Inkjet printing was extensively explored as a tool to produce personalised ODFs, but it… read more here.
Keywords: orodispersible films; micro dispensing; personalised orodispersible; personalised odfs ... See more keywords
In Vitro Oral Cavity Model for Screening the Disintegration Behavior of Orodispersible Films: A Bespoke Design.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.12.025
Abstract: The availability of biorelevant methods for the disintegration study of pharmaceutical orodispersible dosage forms is required. The disintegration of orodispersibles should be assessed using in vitro methods that can combine biorelevant volumes of disintegration medium and… read more here.
Keywords: orodispersible films; disintegration; disintegration behavior; model ... See more keywords
Understanding the Impact of Multi-factorial Composition on Efficient Loading of the Stable Ketoprofen Nanoparticles on Orodispersible Films using Box-Behnken Design.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2021.10.016
Abstract: The purpose of the present study was to prepare Orodispersible films (ODFs) loaded with ketoprofen nanoparticles (KT-NP). The Box-Behnken design was constructed in developing and optimizing the KTF-NP-ODFs. The effect of independent variables: Soluplus® concentration… read more here.
Keywords: ketoprofen nanoparticles; orodispersible films; box behnken; behnken design ... See more keywords
Outlining critical quality attributes (CQAs) as guidance for the development of orodispersible films
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2016.1199567
Abstract: Abstract Context: Orodispersible films have gained increasing relevance as a novel dosage form. Associated to their particular processing and multicomponent composition, there are a vast number of reasons to establish helpful development guidance, gathering simultaneously… read more here.
Keywords: orodispersible films; quality attributes; critical quality; guidance ... See more keywords
Printing Methods in the Production of Orodispersible Films
Sign Up to like & getrecommendations! Published in 2021 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-021-01990-3
Abstract: Orodispersible film (ODF) formulations are promising and progressive drug delivery systems that are widely accepted by subjects across all the age groups. They are traditionally fabricated using the most popular yet conventional method called solvent… read more here.
Keywords: orodispersible films; methods production; printing methods; method ... See more keywords
Nanosized-Loratadine Embedded Orodispersible Films for Enhanced Bioavailability: Scalable Preparations and Characterizations.
Sign Up to like & getrecommendations! Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02230-y
Abstract: The patient-centric strategy urges the pharmaceutical companies to develop orodispersible films (ODF) as a new approach for pediatrics. However, the most common ODF-fabricated method, solvent casting, is facing the safety challenges of safety during manufacturing.… read more here.
Keywords: drug; orodispersible films; loratadine embedded; nanosized loratadine ... See more keywords
Development of Optimized Sumatriptan–Prochlorperazine Combined Orodispersible Films Without Disintegrant: in vitro, ex vivo and in vivo Characterization
Sign Up to like & getrecommendations! Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02307-8
Abstract: Sumatriptan succinate and prochlorperazine maleate are a clinically proven combination for treating migraine and associated nausea and vomiting. Classical oral dosage forms are not frequently workable in migraine because of the associated nausea/vomiting, and no… read more here.
Keywords: vivo; orodispersible films; development optimized; sumatriptan prochlorperazine ... See more keywords
Effects of Various Drying Times on the Properties of 3D Printed Orodispersible Films
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14020250
Abstract: Orodispersible films are an innovative dosage form. Their main advantages are the application comfort and the possibility of personalization. This work aimed to evaluate the influence of different drying times on the properties of orodispersible… read more here.
Keywords: moisture content; time; orodispersible films; times properties ... See more keywords