Orotic acid protects pancreatic β cell by p53 inactivation in diabetic mouse model.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.10.060
Abstract: Impairment of pancreatic β cells is a principal driver of the development of diabetes. Restoring normal insulin release from the β cells depends on the ATP produced by the intracellular mitochondria. In maintaining mitochondrial function,… read more here.
Keywords: cell; acid protects; p53; acid ... See more keywords
Highly Water-Soluble Orotic Acid Nanocrystals Produced by High-Energy Milling.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.12.015
Abstract: Orotic acid (OA), a heterocyclic compound also known as vitamin B13, has shown potent antimalarial and cardiac protection activities; however, its limited water solubility has posed a barrier to its use in therapeutic approaches. Aiming… read more here.
Keywords: high energy; water; orotic acid; energy milling ... See more keywords
Orotic Acid as a Bifunctional Additive for Regulating Crystallization and Passivating Defects toward High-Performance Formamidinium-Cesium Perovskite Solar Cells.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c15928
Abstract: Formamidinium-cesium (FA-Cs) perovskites are an attractive candidate for perovskite solar cells (PSCs) with high stability, but they tend to suffer from high intrinsic defect density, especially at grain boundaries. Herein, a common heterocyclic conjugated molecule,… read more here.
Keywords: bifunctional additive; solar cells; formamidinium cesium; orotic acid ... See more keywords
P123 Maternal pernicious anaemia associated with anorexia and ketotic hypoglycaemia in a child with methylmalonic acid and orotic acid excretion in the urine – a case report
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2019-epa.478
Abstract: Case report A 13 month-old baby girl presented with vomiting and refusal to feed; she was mostly breast feeding. On examination, she appeared off form, underweight, hypotonic and pale. Bedside testing revealed a low blood… read more here.
Keywords: excretion; acid; orotic acid; case report ... See more keywords
Synthesis of orotic acid derivatives and their effects on stem cell proliferation
Sign Up to like & getrecommendations! Published in 2020 at "Open Chemistry"
DOI: 10.1515/chem-2020-0096
Abstract: Abstract Orotic acid, a natural product, is involved in many biological processes. Human mesenchymal stem cells (hMSCs) have the potential of self-renewable and proliferation. They are commonly isolated from the bone marrow aspirates of large… read more here.
Keywords: stem cells; orotic acid; stem cell; proliferation ... See more keywords
Sea Cucumber Saponins Derivatives Alleviate Hepatic Lipid Accumulation Effectively in Fatty Acids-Induced HepG2 Cells and Orotic Acid-Induced Rats
Sign Up to like & getrecommendations! Published in 2022 at "Marine Drugs"
DOI: 10.3390/md20110703
Abstract: The sulfated echinoside A (EA) and holothurin A (HA) are two prominent saponins in sea cucumber with high hemolytic activity but also superior lipid-lowering activity. Deglycosylated derivatives EA2 and HA2 exhibit low hemolysis compared to… read more here.
Keywords: cells orotic; lipid accumulation; orotic acid; fatty acids ... See more keywords