Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function
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DOI: 10.26508/lsa.201900431
Abstract: KRAS-dependent cancer cell growth is inhibited by disrupting phosphatidylserine transport to the plasma membrane by genetic knockdown of lipid exchangers ORP5 and ORP8 or by inhibition of PI4KIIIα. The small GTPase KRAS, which is frequently… read more here.
Keywords: ptdser; content; kras function; orp5 orp8 ... See more keywords